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DIT HIV
| Question | Answer |
|---|---|
| gp41 | env gene protein responsible for fusion and entry of HIV into host cell |
| gp120 | env gene protein that grabs CCR5 on MP, and CCXR4 on T cells. |
| p24 | gag gene protein, capsid. |
| reverse transcriptase | pol gene protein |
| synthesizes dsDNA from RNA | reverse transcriptase |
| diploid genome = 2 molecules of RNA | HIV |
| what happens during the latent phase of HIV infection | virus replicates in lymph nodes |
| when CD4<400, increased risk of contraction | oral thrush, tinea pedis, reactivation VZV, reactivation TB, bacterial infx |
| when CD4<200, increased risk of contraction | reactivation HSV, crytosporidiosis, Isospora, dissemintaed coccidioidomycosis, pneumocystis |
| when CD4<100, increased risk of contraction | candidal esophagitis, toxoplasmosis, histoplasmosis |
| when CDr<50, increased risk of contraction | CMV retinitis and esophagitis, dissemintaed MAC, cryptococcal meningoencephalitis. |
| -navir | Protease inhibitors |
| Didanosine, Stavudine, Lamivudine, Zidovudine, Zalcitabine, abacavir | Nucleotide Reverse Transcriptase Inhibitors (NRTIs) |
| competitively inhibit nucleotide binding to reverse transcriptase and terminate the DNA chain because they don't have a 3'-OH group | NRTIs |
| Nevaripine, Efavirenz, Declaviridine | NNRTIs |
| noncompetitively inhibit reverse transcriptase | NNRTIs |
| Enfurvitide | fusion inhibitor |
| binds viral gp41 subunit, blocking entry and replication | enfurvitide |
| maraviroc | CCR5 antagonist |
| inhibits gp120 conformational change | maraviroc |
| raltegravir | integrase inhibitor |
| GI intolerance | protease inhibitors |
| Inhibit cytochrome P450 | protease inhibitors |
| lipodystrophy and hyperglycemia | saquinavir, indinavir, amprenavir (Protease Inhibitors) |
| Pancreatitis | ritonavir (PI) |
| Nephrolithiasis | indinavir (PI) |
| Pancreatitis and peripheral neuropathy | Didanosie, Zalcitabine, Stavudine (NRTI) |
| Hepatic steatosis | Didanosine, Stavudine (NRTI) |
| Hypersensitivity reactions | Abacavir |
| Rash | NNRTIs |
| False positive drug test to cannainoids | Efavirenz (NNRTI) |
| Confusion | Efavirenz (NNRTI) |
| Lactic acidosis | NRTIs (but not abacavir) |
| megaloblastic anemia and peripheral neuropathy | zidovudine |
| hyperglycemia, DM, and lipid abnormalities | Saquinavir, Indinavir, Amprenavir (PI) |
| Given to pregnant women with HIV | zidovudine |
| Regiment for occupational HIV exposure | zidovuidine + lamivudine |
| a combination of different classes of medication used to attack the HIV at different points in its replication/infection cycle in order to control the infection and avoid resistance | HAART |
Created by:
kayjames
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