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DIT HIV

QuestionAnswer
gp41 env gene protein responsible for fusion and entry of HIV into host cell
gp120 env gene protein that grabs CCR5 on MP, and CCXR4 on T cells.
p24 gag gene protein, capsid.
reverse transcriptase pol gene protein
synthesizes dsDNA from RNA reverse transcriptase
diploid genome = 2 molecules of RNA HIV
what happens during the latent phase of HIV infection virus replicates in lymph nodes
when CD4<400, increased risk of contraction oral thrush, tinea pedis, reactivation VZV, reactivation TB, bacterial infx
when CD4<200, increased risk of contraction reactivation HSV, crytosporidiosis, Isospora, dissemintaed coccidioidomycosis, pneumocystis
when CD4<100, increased risk of contraction candidal esophagitis, toxoplasmosis, histoplasmosis
when CDr<50, increased risk of contraction CMV retinitis and esophagitis, dissemintaed MAC, cryptococcal meningoencephalitis.
-navir Protease inhibitors
Didanosine, Stavudine, Lamivudine, Zidovudine, Zalcitabine, abacavir Nucleotide Reverse Transcriptase Inhibitors (NRTIs)
competitively inhibit nucleotide binding to reverse transcriptase and terminate the DNA chain because they don't have a 3'-OH group NRTIs
Nevaripine, Efavirenz, Declaviridine NNRTIs
noncompetitively inhibit reverse transcriptase NNRTIs
Enfurvitide fusion inhibitor
binds viral gp41 subunit, blocking entry and replication enfurvitide
maraviroc CCR5 antagonist
inhibits gp120 conformational change maraviroc
raltegravir integrase inhibitor
GI intolerance protease inhibitors
Inhibit cytochrome P450 protease inhibitors
lipodystrophy and hyperglycemia saquinavir, indinavir, amprenavir (Protease Inhibitors)
Pancreatitis ritonavir (PI)
Nephrolithiasis indinavir (PI)
Pancreatitis and peripheral neuropathy Didanosie, Zalcitabine, Stavudine (NRTI)
Hepatic steatosis Didanosine, Stavudine (NRTI)
Hypersensitivity reactions Abacavir
Rash NNRTIs
False positive drug test to cannainoids Efavirenz (NNRTI)
Confusion Efavirenz (NNRTI)
Lactic acidosis NRTIs (but not abacavir)
megaloblastic anemia and peripheral neuropathy zidovudine
hyperglycemia, DM, and lipid abnormalities Saquinavir, Indinavir, Amprenavir (PI)
Given to pregnant women with HIV zidovudine
Regiment for occupational HIV exposure zidovuidine + lamivudine
a combination of different classes of medication used to attack the HIV at different points in its replication/infection cycle in order to control the infection and avoid resistance HAART
Created by: kayjames