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DIT/FA antiviral

p195-197

QuestionAnswer
prophylaxis for influenza A amantadine
imhibits CMV DNA polymerase gangciclovir
used in tx for chrnoic hep C ribavirin
first line for HSV or EBV acyclovir
blocks viral penetration and uncoating (M2 protein) amantadine
treats both influenza A and B zanamivir, oseltamivir
second line for CMV retinitis Foscarnet
Derivative of amantadine with fewer side effects because it does not cross the bbb Rimantidine
inhibits viral DA polymerase when phosphorylated by viral thymidine kinase Acyclovir
also causes the release of dopamine from intact nerve terminals amantadine
resistance due to mutated M2 protein amantadine
inhibits influenza neuraminidase, decreasing the release of progeny virus zanamivir, oseltamivir
inhibits synthesis of guanine nucleotides by competitively inhibiting IMP dehydrogenase Ribavirin
SE: ataxia, dizziness, slurredd speech, anticholinergic amantadine
SE: hemolytic anemia. severe teratogen ribavirin
monophosphorylated by HSV/VZV THYMIDINE kinase Acyclovir
preferentially inhibits viral DNA polymerase by chain termination Acyclovir, Ganciclovir
herpes zoster Famciclovir
phosphorylated by CMV viral kinase of HSV/VZV thymidine kinase gangciclovir
SE: leukopenia, neutropenia, thrombocytopenia, renal tox gangciclovir
viral DNA polymerase inhibitor that binds to the pyrophosphate binding site of the enzyme. foscarnet
SE: nephrotoxicity foscarnet
Created by: kayjames
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