click below
click below
Normal Size Small Size show me how
DIT/FA antiviral
p195-197
Question | Answer |
---|---|
prophylaxis for influenza A | amantadine |
imhibits CMV DNA polymerase | gangciclovir |
used in tx for chrnoic hep C | ribavirin |
first line for HSV or EBV | acyclovir |
blocks viral penetration and uncoating (M2 protein) | amantadine |
treats both influenza A and B | zanamivir, oseltamivir |
second line for CMV retinitis | Foscarnet |
Derivative of amantadine with fewer side effects because it does not cross the bbb | Rimantidine |
inhibits viral DA polymerase when phosphorylated by viral thymidine kinase | Acyclovir |
also causes the release of dopamine from intact nerve terminals | amantadine |
resistance due to mutated M2 protein | amantadine |
inhibits influenza neuraminidase, decreasing the release of progeny virus | zanamivir, oseltamivir |
inhibits synthesis of guanine nucleotides by competitively inhibiting IMP dehydrogenase | Ribavirin |
SE: ataxia, dizziness, slurredd speech, anticholinergic | amantadine |
SE: hemolytic anemia. severe teratogen | ribavirin |
monophosphorylated by HSV/VZV THYMIDINE kinase | Acyclovir |
preferentially inhibits viral DNA polymerase by chain termination | Acyclovir, Ganciclovir |
herpes zoster | Famciclovir |
phosphorylated by CMV viral kinase of HSV/VZV thymidine kinase | gangciclovir |
SE: leukopenia, neutropenia, thrombocytopenia, renal tox | gangciclovir |
viral DNA polymerase inhibitor that binds to the pyrophosphate binding site of the enzyme. | foscarnet |
SE: nephrotoxicity | foscarnet |