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NURS572 Ch 30

migraine headaches

classes of migraine treatment analgesic, anti-inflamm, opioids, 5-HT 1B/1D agonists
MOA of serotonin 5HT 1B1D agonists bind receptor which prevents the binding of CGRP. Net effect decrease inflamm, vasoCON
dosing of this class limited to 1-2 xs per week, avoid rebound effect
SEs of this class chest pressure/pain (non-angina), pulmonary vasoCON, esophogeal/broncho/intercostal spasm, rare angina
this prototype given oral, nasal, SQ sumatriptan
oral melt-in-mouth rizatriptan, zolmitriptan
oral-traditional almo-ele-frova-nara triptans
also available in nasal spray zolmitriptan
3 drug classes for prophylactic tx beta blockers (propanolol), calcium channel blockers (verapamil) and TCAs (amitriptyline)
Created by: lorrelaws