Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
NURS 572 Pharm 28
Opioids, nonopioid centrally acting analgesics
| Question | Answer |
|---|---|
| MOA opioid agonists | activate Mu (--> resp dep) and Kappa (--> psychotomimetic, diuretic) |
| strong opioids given oral, IM, rectal (3) | morphine, hydromorphone, oxymorphone |
| very short acting opioids (2) | meperidine, remifentanyl |
| meperidine uses/ADRs | labor/delivery, neurotoxic metabolite (avoid drug), anticholinergic (watch tachy) |
| remifentanyl | break through pain, short acting, metab by plasma esterases |
| long-acting opioids (2) | methadone, levorphanol |
| methadone uses | pain, maintenance, detox |
| levorphanol class | long acting opiate agonist |
| chronic pain opioids (3) | fentanyl, alfentanil, sufentanyl |
| routes of admin fentanyls | inj, ITS, transdermal, lozenge, lollipop, buccal, nasal spray |
| moderate efficacy opioids (3) | codeline, oxycodone, hydrocodone |
| codeine | combo, very limiting SEs n/v |
| oxycodone | alone or combo |
| hydrocodone | combo only |
| MOA mixed agonist/antagonist opioids | activate either mu/kappa, antagonize the other |
| benefit/limitation mixed opioids | raises resp depr ceiling(+), but pyschotomimetic reactions |
| name 4 mixed opioids | pentazocaine, nalbuphine, butorphanol, buprenorphine |
| which 2 mixed opioids contraindicated cardiac pts due to increased cardiac load | pentazocaine (contains naloxone too), butorphanol |
| class of nalbuphine | mixed opioid |
| class of buprenorphine | mixed opioid with diff actions at mu/kappa |
| class of penazocaine | mixed opioid, oral combo with naloxone, or injection |
| name 4 opiate antagonists that can lead to withdrawal if pt is opioid tolerant | naloxone, naltrexone, methyl-naltrexone, alvimopan |
| class, use naloxone | opioid antagonist. rapid, short acting block mu/kappa. detox/cravings |
| class, use of naltrexone | opioid antagonist. maintenance post detox. doesn't prevent cravings |
| class, use of alvimpoan | only post-op ileus (antagonizes SE of urinary retention). strict controls, in pt only |
| opioid ADRs that do NOT develop tolerance | miosis, consitpation |
| opioid ADRS where tolerance develops | urinary retention, biliary colic, ICP increases, orthostatic hypoTN, emesis, sedation, decreased respirations, cough suppression |
| MOA non-opioid central acting analgesics | weak mu agonist, but either blocks reuptake Ser, Nor or both |
| class, moa tramadol | non opioid centrally acting analgesic blocks reuptake of nor, ser |
| class, moa tapentadol | non opioid centrally acting analgesic blocks reuptake of ser only |
Created by:
lorrelaws
Popular Nursing sets