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protein synethesis inhibitors

What drug classes inhibit protein synthesis? buy AT 30, CCELL at 50: Aminoglycosides, tetracyclines. Chloramphenicol, Clindamycin, Erythromycin, Lincomycin, Linelozid
binds 23s RNA and interacts with the bacterial initiaton complex. for MRSA and VRE linezolid
5 aminoglycosides GNATS: Gentamycin, Neomycin, Amikacin, Tobramycin, Streptomycin
Clinical uses for aminoglycosides? severe gram negative ROD infections
Synergistic with aminoglycosides beta lactams
Why are aminoglycosides ineffective against anaerobes They require O2 for uptake
Side effects of aminoglycosides NOT: Neprotoxic, Ototoxic, Teratogenic
What drugs have ototoxicity and nephrotoxicity as side effects? Aminoglycosides, Vancomycin, Loop diuretics, Cisplatin
Clinical uses for tetracyclines VACUUM THe BedRoom: Vibrio, Acne, Chlamydia, Ureaplasma, M. pn, Tularemia, H.pylori, BOrrelia, rickettsia
What should you never take with tetracyclines milk, antacids or iron (Ca, Mg, Fe - because divalent cations inhibit absorption)
Side effects of tetracyclines GI distress, teeth discoloration, photosensitivity, inhibits bone growth
Clinical uses for macrolides? PUS: atypical Pneumonia, URIs, STDs Gram Positives
Most common cause of non-adherence with macrolide use? GI discomfort
Clinical use of chloramphenicol? Meningitis (H flu, NM, St Pn)
Side effects of chloramphenicol? Anemia, aplastic anemia, gray baby syndrome
What causes gray baby syndrome? chloramphenicol
What causes gray man syndrome? amiodarone
what causes red man syndrome? vancomycin
binds peptidyl transferase of the 50S ribosomal subunit Streptogramin A
prevents protein chain extension Streptogramin B
streptogramin indications MRSA, VRe, staph and strep skin infx
streptogramin side effects hepatotoxicity, pseudomembranous colitis
ckincal uses of clindamycin anaerobic infxn, aspiration pneumonia, lung abscesses, skin infx d2 MRSA
side effects of clindamycin pseudomembranous colitis, fever, diarrhea
mechanism of sulfonamides folic acid inhibitors. PABA antimetabolites inhibit DIHYDROPTERATE SYNTHETASE
mechanism of trimethoprim folic acid inhibitors. inhibits DIHYDROFOLATE REDUCTASE
Clinical uses of TMP-SMX UTIs, Shigella, salmonella, pn jiroveci. G+, G-, Nocardia, chlamydia
What other drugs should be avoided in pts with sulfa allergy celecoxib, furosemide, probenecid, thiazides, TMP-SFX, sulfasalazine, sulfonylureas, acetazolamide, sulfonamide abx, sumatriptans
reduced by bacterial proteins to a reactive intermediate taht inactivates bacterial ribosomes nitrofurantoin
for UTI cstitis by E coli or staph saprophyticus nitrofurantoin
side effects of nitrofurantoin nausea, HA, flatulence
What organisms most commonly cause UTIs? E coli (80%), Proteus, Klebsiella, Staph saphro
What drugs have photosensitivity reactions? Sulfonamides, Amiodarone, Tetracyclines
What drugs can cause Steven's Johnson syndrome? -cillins, sulfas, seizures (ethosuxamide, lamotrigene, carbamazepine, phenobarbital, phenytoin) and allopurinol
Quinolone mechanism inhibit DNA gyrase (topoisomerase II)
clinical uses for fluoroquinolones? gram negative rods of G/U + GI tract infx. (pseudomonase, neisseria), gram +
side effects of fluroguinolones GI upset, tendonitis and tendon rupture
Metronidazole uses (GET GAP) Giardia, entamoeba, trichomonas, gardnerella, anaerobes, h pylori
What drugs are used in anaerobic infections? Metronidazole, Clindamycin, Imipenem/cilastatin, meropenem
H pylori triple therapy PPI, Clarithromyin, Amoxicillin or Metronidazole
what drugs cause a disulfiram like reaction some cephalosporins, Procarbazine, Metronidazole, 1G sulfonylureas
What abx are restricted to topical use d2 nephrotoxicity Neomycin
Clincal uses of polymxin resistant Gram negatives
Side effects of polymyxin Neurotoxic, Acute renal tubule necrosis
Drugs effective against pseudomonas polymyxins, fluoroquinolones, cefepime, aztreonam, aminoglycosides, extended spectrum penicillins, 3G cephalosporins
Created by: kayjames



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