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DIT immuno
DIT/FA immuno
| Question | Answer |
|---|---|
| CD surface marker displayed only by Helper T cells | CD4 |
| CD surface marker displayed only by cytotoxic T cells | CD8 |
| CD surface marker found on all T cells (but not NK cells) | CD3 |
| CD surface markers used to ID B cells | CD19,20,21 |
| CD surface markers that inhibit compliment C9 binding | CD55, 59 |
| Cd surface marker found on all NK cells and binds the constant region of IgG | CD16 |
| Endotoxin receptor found on macrophages | CD14 |
| Cytokines that promotes B cell growth and differentiation | IL-4, IL-5 |
| Cytokines that are produced by Th1 cells | IL-2, IFNgamma |
| Cytokines that are produced by Th2 cells | IL-4, IL-5, IL-10 |
| Cytokine involved in growth and activation of eosinophils | IL-5 |
| cytokine secreted by helper T cells and activates macrophages | IFN-gamma |
| cytokine that inhibits macrophage activation | IL-10 |
| pyogens secreted by monocytes and macrophages | IL-1, IL-6, TNFalpha (acute phase cytokines) |
| cytokine that inhibits the production of Th1 cells | IL-10 |
| Cytokine that inhibits the production of Th2 cells | IFN-gamma |
| Cytokine that mediates inflammation | Il-1, IL-6, TNFalpha |
| Cytokine that enhances the synthesis of IgE and IgG | IL-4 |
| Cytokine that enhances synthesis of IgA | IL-5 |
| Cytokines released by virally infected cells | IFNalpha, IFNbeta |
| Cytokine that supports T cell proliferation, differentiation, and activation | IL-2 |
| What composes the coding region for each specific antigen receptor on B and T cells | Rearrangements of DNA segments named variable (V), diversity (D), and joining (J) |
| How does the rearrangement process begin? | with breaks in the dsDNA a recombination signal sequences (RSSs) that flank the V,D, and J coding regions |
| How is V(D)J recombination initiated? | by the recombination activating gene complex (RAG 1 and 2) |
| What happens if there are mutations in either of the RAG genes? | the inability to initiate V(D)J rearrangements causes an arrest of B and T cell development |
| Immunoglobin associated with allergies because it is bound by mast cells and basophils and causes them to degranulate and release their histamine | IgE |
| Comprises 70-75% of the total immunoglobulin pool | IgG |
| Present in large quantities on the membrane of many B cells | IgM, IgD |
| Crosses the placenta and confers imunity to neonates in the first few months of life | IgG |
| Can occur as a dimer | IgA |
| Largely confined to the intravascular pool and is the predominant early antibody frequently seen in the immune response to infectious organisms and with complex antigens | IgM |
| Distributed evenly between the intravascular and extravascular pools | IgG |
| The predominant ig in mucoserous secretions like saliva, colostrum, milk, tracheobronchial secretions, and genitourinary secretions | IgA |
| Can be a pentamer | IgM |
| How do you diagnose PNH | With Ham's test |
| Hams test | RBCs lyse at low PH |
| Triad of PNH | Hemosiderinuria, Chronic intravascular hemolysis, Thrombosis |
| Anemia, Jaundice, Hydrops fetalis, I/U death | clinical features of erythroblastosis fetalis in the neonate |
| Poststreptococcal glomerulonephritis hypersensitivity | 3 |
| Asthma hypersensitivity | 1 |
| Rheumatic fever hypersensitivity | 2 |
| Tuberculosis skin test (PPD) hypersensitivity | 4 |
| Allergies, anaphylaxis, and hay fever hypersensitivity | 1 |
| Polyarteritis nodosa hypersensitivity | 3 |
| Serum sickness hypersensitivity | 3 |
| ABO blood type incompatibility hypersensitivity | 2 |
| Poison Ivy hypersensitivity | 4 |
| Eczema hypersensitivity | 1 |
| Contact dermatitis hypersensitivity | 4 |
| Goodpasture's syndrome hypersensitivity | 2 |
| causes an elevated ESR | Polymyalgia rheumatica, temporal arteritis, disease activity in RA and SLE, infxn, inflammation (osteomyelitis), malignancy |
| Which complement is responsible for neutrophil chemotaxis? | C5a |
Created by:
kayjames
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