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Drug reactions

FA/DIT drug reactions

QuestionAnswer
Atropine-like (anticholinergic) side effects TCAs, low potency neuroleptics, 1G antiH, amantadine
coronary vasospasm cocaine, triptans, amphetamines, ergotamines
cutaneous flushing (VANC) Vancomycin, Adenosine, Niacin, CCBs
dilated cardiomyopathy Doxorubicin, Daunorubicin
torsades de pointes (prologed QT) class III/ Ia antiarrhythmics, macrolides, haloperidol, risperidone, methandone, PIs, chloraquine, mefloquine
Agranulocystosis Clozapine, Carbamazepine, Colchice, PTU, methimazole, dapsone
Aplastic Anemia chloramphenicol, benzene, NSAIDS, PTU, methimazole
Direct Coombs-positive hemolytic anemia Methyldopa
Gray baby syndrome Chloramphenicol
G6PD def hemolysis (IS PAIN) INH, Sulfonamides, Primaquine, ASA, Ibuprofen, Nitrofurantoin. +Dapsone, Napthalene, Fava Beans
Megaloblastic anemia Phenytoin, Methotrexate, Sulfa drugs
Thrombosis OCPs
Thromboxytopenia Heparin, H2 blockers
Cough Ace inhibiters
Pulmonary fibrosis Bleomycin, Amiodarone, Busulfan
Acute cholestatic hepatitis Erythromycin Estolate
Focal to massive hepatic necrosis halothane, valproic acid, acetaminophen, amanita phalloides
Hepatitis INH
Pseudomembranous Clindamycin, Ampicillin (any abx)
Adrenocortical insufficiency glucocorticoid withdrawal
Gynecomastia (Some Drugs Create Awesome Knockers) Spironolactone, Digitalis, Cimetidine, Alcohol, Ketoconazole. + Estrogens and MJ
Hot flashes SERMS: Tamoxifen, Clomiphene
Hypothyroidism Lithium, Amiodarone
Gingival Hyperplasia Phenytoin
Gout Furosemide, Thiazides
Osteoporosis corticosteroids, heparin
Photosensitivity (SAT) Sulfonamides, Amiodarone, Tetracycline
Rash (Steven Johnson syndrome) Seizure, Sulfa, -cillins, allopurinol
SLE like syndrome (SHIPP) sulfonamide, hydralazine, INH, Procainamide, Phenytoin
Tendonitis, tendon rupture, cartilage damage Fluoroquinolones
Fanconi's syndrome expired tetracycline, heavy metals, wilson's disease
Interstitial nephrtitis methicillin, NSAIDs, furosemide
Hemorrhagic cystitis cyclophosphamide, ifosfamide
Cinchonism quinidine, quinine
nephrogenic DI lithium, demeclocycline
parkinson-like syndrome haloperidol, chlorpromazine, reserpine, metoclopramide, MPTP
seizures bupropion, imipenem/cilastatin, isoniazid, evening primose oil, enflouracil, withdrawal
tardive dyskinesia antipsychotics
disulfiram-like reaction metronidazole, certain cephalosporins, procarbazine, 1G sulfonylureas
nephrotoxicity/neurotoxicity polymyxins
nephrotoxicity/ototoxicity aminoglycosides, vancomycin, loop diuretics, cisplatin
Created by: kayjames
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