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Ch.5 Antibiotics

Major Classes and MOA

Protein Synthesis inhibitors Aminoglycosides, Choramphenicol, Erythromycin (+macrolides), Tetracycline
Folate Inhibitors Sulfonamides, Trimethoprim
Cell Wall Pens and Cephalosporins, Vancomycin
Topoisomerase inhibitor Quinolones (-OXACIN)
What is the only protein synthesis inhibitor that is bactericidal? Aminoglycosides (inhibits initiation of p.synthesis)
Which agents are Aminoglycosides? Gentamicin Amikacin Neomycin Streptomycin Tobramycin
AGs work on what type of organisms? ONLY aerobic Gram negatives!
Major side effect of AGs? ototoxicity. (severely increased with use of Loops)
Vancomycin MOA inhibits cell membrane and cell wall synthesis via peptidogylcan inhibition --> CIDAL
Major SE and contras of Quinolones Contra in <16 & caution with >60--> TENDON RUPTURE/joints increased QT interval
Chloramphenicol MOA protein synthesis inhibitor via blocking peptidyl transferase --> STATIC
Tetracyclines include which agents? Doxycycline Tetracycline Minocycline Tigecycline
Tetras MOA inhibit protein synthesis via blocking tRNA binding --> STATIC
Sulfonamides and Trimethroprim both have MOA involving folate. How do they differ? Sulfa-- prevents folate synthesis Trimethroprim-- inhibits folate use (usually the two agents are used together)
Created by: caldwekl



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