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Ch.5 Antibiotics
Major Classes and MOA
Question | Answer |
---|---|
Protein Synthesis inhibitors | Aminoglycosides, Choramphenicol, Erythromycin (+macrolides), Tetracycline |
Folate Inhibitors | Sulfonamides, Trimethoprim |
Cell Wall | Pens and Cephalosporins, Vancomycin |
Topoisomerase inhibitor | Quinolones (-OXACIN) |
What is the only protein synthesis inhibitor that is bactericidal? | Aminoglycosides (inhibits initiation of p.synthesis) |
Which agents are Aminoglycosides? | Gentamicin Amikacin Neomycin Streptomycin Tobramycin |
AGs work on what type of organisms? | ONLY aerobic Gram negatives! |
Major side effect of AGs? | ototoxicity. (severely increased with use of Loops) |
Vancomycin MOA | inhibits cell membrane and cell wall synthesis via peptidogylcan inhibition --> CIDAL |
Major SE and contras of Quinolones | Contra in <16 & caution with >60--> TENDON RUPTURE/joints increased QT interval |
Chloramphenicol MOA | protein synthesis inhibitor via blocking peptidyl transferase --> STATIC |
Tetracyclines include which agents? | Doxycycline Tetracycline Minocycline Tigecycline |
Tetras MOA | inhibit protein synthesis via blocking tRNA binding --> STATIC |
Sulfonamides and Trimethroprim both have MOA involving folate. How do they differ? | Sulfa-- prevents folate synthesis Trimethroprim-- inhibits folate use (usually the two agents are used together) |