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DIT RDE
Rate determining enzymes of metabolic processes
| Process | Enzyme |
|---|---|
| Glycolysis | Phosphofructokinase-1 (PFK-1) |
| Gluconeogenesis | Fructose-1,6-bisphosphatase |
| TCA cycle | Isocitrate dehydrogenase |
| Glycogen synthesis | Glycogen synthase |
| Glycogenolysis | Glycogen phosphorylase |
| HMP Shunt | Glucose-6-phosphate-dehydrogenase (G6PD) |
| De novo pyrimidine synthesis | Carbamoyl phosphate synthetase II |
| De novo purine synthesis | Glutamine-PRPP amidotransferase |
| Urea cycle | Carbamoyl phosphate synthetase I |
| Fatty Acid Oxidation | Carnitine Acyltransferase I |
| Fatty Acid Synthesis | Acetyl-CoA carboxylase (ACC) |
| Ketogenesis | HMG CoA synthase |
| Cholesterol synthesis | HMG CoA reductase |
| Heme synthesis | Aminolevulinate Synthase |
| Bile synthesis | 7-alpha hydroxylase |