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Biomed Endocrine

Chapter 16 biomed: endocrine system

QuestionAnswer
Biomed Chapter 16 Endocrine System
Neuroendocrine system when the nervous system and the endocrine system work together to perform communication, integration, and control
Hormone endocrine system secretes chemicals via bloodstream, whereas nervous does it between neurons
Target cells the tissues/organs/cells that the hormones are going to
Hormones vs. neurotransmitters hormomes are long lasting and can control almost every cell in the body, while the nervous system can only control muscles and glands that ethey enervate, and it is short-lived
Endocrine glands are ductless glands, exocrine glands are have ducts
Neurosecretory tissue modified neurons that secrete chemical messengers that diffuse into the blood stream rather than across a synapse, considered a hormone not a neurotransmitter
Tropic hormones hormones that targe other endocrine glands and stimulate their growth and secretion
Sex hormone target reproductive tissues
Anabolic hormones stimulate anabolism in target cells
Steroid hormones manufactured by endocrine cells from cholesterol, a lipid, characteristic chemical group at the core of each molecule, lipid-soluble so can pass through phospholipid membrane of target cells
Steroid hormone examples cortisol, aldosterone, estrogen, progesterone, testosterone
Steroid hormones are able to… pass through the phospholipid plasma membrane of cells, attaches to the nucleus
Nonsteroid hormones synthesized from amino acids rather than from cholesterol, some are proteins
Protein hormone examples insulin, parathyroid hormone
Glycoprotein hormones protein hormones that have a carbohydrate group
Peptide hormones smaller than protein hormones
Amino acid derivative hormones derived from a single amino acid molecule
Two subgroups of amino acid derivative hormones amine hormones and ones produced in the thyroid gland that has Iodine in it
Amine hormones synthesized by modifying a singlemolecule of tyrosine, epinephrine and norephinephrine, produced by neurosecretorycells and by neurons
Target any cell with one or more receptors for a particular hormone is the target of that hormone
Synergism hormones work together to enhance each other’s influence on a target cell
Permissiveness when a small amount of one hormone allows a second hormone to have aits full effect on a target cell; the first hormone ‘permits’ the full action of the second
Antagonism one hormone produces the opposite effect of another rhormone, can be used to “fine tune” the activity of target cells with great accuracy
Endocrine system produces more hormones because to make sure it hits the targets
Steroid hormones can’t be soluble in blood plasma, so it atataches to soluble plasma proteins,
Steroid hormones receptor cells are found in inside the cell rather than on the plasma membrane, passes intothe nucleus where ti binds to a mobile receptor molecule to form a hormone-receptor complex
Mobile receptor-hypothesis steroids move freely in the nucleoplasm
Magnitude fo the target cell’s response is determined by the amount of steroid hormone present
Second messenger hypothesis nonsteroid hormones, the n onsteroid is the first messenger , delivering its chemical message to fixed receptors in the target cell’s membrane, the message is passed into the cell where a second messenger riggers the appropriate cellular changes
Fixed membrane receptor hypothesis same a second messenger hypothesis
The second messenger is different from the steroid messenger because the second messenger amplifies the signal, and operates much more quickly
Hormonal secretion are conteolled with a negative efeedback loop
Hypothalamus controls the pituitary
Prostaglandins lipid molecules that produce a widespread integrative function in the body, rapidly metabolized, a tissue hormone within the same tissue, 16 different, A through I
Things that secrete prostolandins kidneys, lungs, iris, brain, thymus, seminal vesicles
Things like prostaglandins thromboxanes and leiukotrienes
Hypophysis the pituitary gland
Infundibulum the stalk of the pituitary that connects it to the hypothalamus
Two glands of pituitary adenohypophysis (anterior pituitary) and neurohypophysis (posterior pituitary)
Adenohypophysis anterior pituitary
Parts of the adenohypophysis pars anterior and pars intermedia
Pars anterior major portion of anterior pituitary
Cells in pituitary chromophobes, acidophils, basophils
Number of secretions of anterior pituitary 5
Somatotrophs secrete growth hormone, anterior pituitary
Corticotrophs anterior pituitary, secrete adrenocorticotropic homone
Thyrotrophs anterior pituitary, secrete thyroid-stimulating hormone
Lactotrophs anterior pituitary, secrete prolactin
Gonadotrophs secrete luteinizing hormone and follicle stimulating hormone, anterior pituitary
Somatotroping growth hormone, stimulates bodily growth by stimulating the liver to produce growth factors, stimulates fat metabolism, hyperglycemic effect (causes blood glucose to rise)
Antagonist to growth hormone Insulin which is hypoglycemic (lowers the blood sugar) while GH raises it
GH affects metabolism promotes protein anabolism lipid mobilization dn catabolism, inhibits glucose metabolism,increases blood glucse levels
Prolactin pruoduced by acidophils in pars anterior, lactogenic hormone, initiates lactation
Hypersecretion too much PRL causes lactation in a nonnursing women
Hyposecretion not enough PRl secretion does not allow milk production
Tropic hormones stimulating effect on other endocrine glands
Principal tropic hormones production location produced and secreted by the basophils of pars anterior
Principal tropic hormones thyroid-stimulating hormone, adrenocorticotropic hormone, follicle stimulating hormone, luteinizing hormone
TSH thyroid stimulating hormone
Thyroid stimulating hormone promotes and maintains the growth and development of thyroid, causes the thyroid to secrete its hormones
ACTH adrenocorticotropic hormone
Adrenocorticotropic hormone promotes and maintains normal growth and development of the cortex fo the adrenal grland, stimulate the adrenal cortex to synthesize and secrete some of its hormones
FSH follicle-stimulating hormone
Follicle-stimulating hormone stimulates structures within orvaries to grow twards maturity, FSH stimulates the follicles, which hold egg cells, to synthesize and secrete estrogen as well as in men to maintain spermatogeneisis
LH lutenizing hormone
Lutenizing hormone stimulates the formation of the corpus luteum of the ovar which is the tissue left behind when an egg is released, secretes progesterone and estrogens, stimulates interstitial cells itn the testes to develop
Gonadotropins FSHa dn LH, stimulate the growth and maintence fo the gonads
Releasing hormones
Hypophyseal prtal system arranglement of blood vessels in which blood exiting one tissue is immeidiately carried to sa second tissue,
General chemical secreted by hypothalamus releasing hormones, travel in hypophyseal portal system
Thyroid is controlled by hypothalamus
GRH growth hormone releasing hormone
GIH growth hormone-inhibiting hormone
CRH corticotrophin-releasing hormone
TRH thyrotropin-releasign hormone
GnRH Gonadotropin-releasign hormone
PRH prolactin-releasing hormone
PIH prolactin-inhibiting hormone
What the body does understress limbic system signals hypothalamus, with secretes it sreleasign hormones into the hypophyseal portal veins, wihc stimulate increased activing by the pituitary’s target structures
Hypothalamus links nervous system to the endocrine system, integrates the two in times of stress
Neurohypophysis storage and release site for antidiuretic hormone (ADH) and oxytocin (OT)
Hypothalamus and brain allow for psychosomatic (mind influencing body) and somatopsychic (body influencing mind)
Sysnthesis of neurohypophysis hormones supraoptic/paraventricular nuclei nurons in the hypothalamus
Antidiuretic hormone controls and prevents a large amout of urine forming, helps body conserve water
Osmoreceptors detects changes in osmotic pressure and tells antidiuretic hormone to absorb more water
Oxytocin stimulate contraction of uterin muscles and causes milk to be ejected during lactation
Lactation and childbirth are a postitive feedback loop
Pineal gland biological clock, regulates eating, sleeping, reproduction, melatonin procution which induces sleep
Seasonal affective disorder severe depression in winter, linked to pineal gland
Thyroid gland made up of two lateral lobes and a narrow connecting ithsmus, pyramidal lob eextending upward from ithsmus
Follicles what makes up the thyroid and where hormones are synthesized
Thyroid colloid thick fluid theat filles follicles, produced by cuboidal cells of follicle wall, contains protein-iodine compounds which are the precursors to thyoid hormones
Thyroglobulins protein-iodine complexes in thyroid colloid that will become thyroid hormones
Thyroid hormone is made up of tetraiodothyronine (thyroxine, T4) and triiodothyronine (T3), t4 has 4 iodine molecules
Thyroid is unique because after synthesizing a preliminary form of its homones, it stores them befor secretion
Where T3 and T4 attach to thyroxine binding globulin and albumin
The principal thyroid hormone T3, much more potent, although 20 times more T4 is rleased, t3 binds more efficiently
Calcitonin CT, produced by thyroid hormone, produced byparafallicular cells, c cells, influencenses processing of calcium by bone cells, decreases calcium by increasing osteo blasts and incibiting osteoclasts antagoinsit = parathyroid hormone
CT calcitonin
Parathyroid glands 4-5, posterior surface of lateral obes o fthyroid
Parathyroid hormone PTH, antagonist to calcium levels, increase release fo calcium into the blood, breaks down bones by increasing osteoclast
Adrenal gland atop the kidneys, made of adrenal cortex and adrenal medulla, medulla=neurosecretory tissue and cortex is endocrine tissue
Adenal cortex parts made of zona glomerulosa, zona fasciculate, and zona reticularis
Zona glomerulosa secretes mineralocorticoids
Zona fasciculata secrete glucocorticoids
Zona reticularis secretes small amount of glucocorticoids an dgonatocorticoids,
All hormones secreted by the adrenal cortex are corticosteroids, which are steroids
Aldosterone mineralocorticoid, maintenance of sodium homeostasis in blood, increases sodium reabsorption in the kidneys, influences potassium and pH levels I blood
Aldosterone is controlled by rennin-angiontensin mechanism
Rennin-angiotensis mechanism steps rennin secreted when blood pressure in kidneys low,causes angiotensinogen converted to angiotensin I,circulats to lungs,by enzymes goes to angiotensin II, circulates to adrenal cortex,stimulates aldosterone, increases water retention,causes rennin to stop
Cortisol glucocorticoid, zona fasciculate, affect every cell in the body
Glococorticoids on amino acids accelerate the breakdown of proteins where they are changed tro glucose in the liver, will result in tissue loss
Glucocorticoids on lipids accelerate mobilization of lipid catabolism, shift to breaking down lipids first
Glucocorticoids in blood pressure allow epinephrine and norepinephrine to produce vasoconstriction effect on blood vessels
Permissiveness allowing another hormone to have full effect
Glucocorticoids and antiinflamation works with epinephyrine to reduce inflammation
Stress and glucocorticoid secreted when stressed because allows more glucose for muscles during fight of light response
Gonadocorticoid sex hormones released from zona fasciculate and zona reticularis
Adrenal medulla neurosecretory tissue, modified sympathetic postganglionic fibers
Two hormones secreted by adrenal medulla epinephrine (adrenaline, 80% of secretions) and norepinephrine
Pancreatic islets , surrounded by acini (secrete digestive enzymes), going by gap junctions so function as a single secretoyr unit
Alpha cells in pancreas, secrete glucagon
Beta cells in pancreas, secrete insulin
Delta cells in pancreas, secrete somatostatin
Pancreatic polypeptice cells secrete pancreatic polypeptide
Most numerous pancreatic islet cells beta cells, ¾ of all
Names of pancreatic islets alpha, beta, delta, pancreatic polypeptide cells
Glucagon produced by alpha cells, increase blood glucose levels by stimulating the conversion fo glycogen to glucose in liver
Insulin produced by betacells, promote th movement fo glucose, amino acids,a dn fatty acids out of blood and into tissue, promotes metablolism
Somatostatin produced by delta cells, regluateing other endocrine cells fo pancreatic islets, inhibits secretion of glucagon, pinsulin,a dn pancreatic polypeptide and GH
Pancreatic polypeptide produced by PP cells, influences digestion nd distribution of food molecules
Gonads primary sex organs
Testosterone an androgen produced in tubules, responsible for sperm and male characteristics
Ovaries produce estrogens and progesterone
Estrogen estradiol and estrone, steroids, maintain female characteristics
Progesterone secreted by corpus luteum, maintains uterus for pregnancy
Placenta produces human chorionic gonadotropin
Human chorionic gonadotropin signals mother to maintain uterine lining
Thymus gland in mediastinum, begins to atrophy in puberty, produces thymosin and thymopoietin
The heart produces atrial natriuretic hormone, secreted by atrium when stretched, promotes looss of sodium which reduces blood volume
Pancreas exocrine function acinar cells
Created by: reidabook
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