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Pharm 36 AntiVirals
LECOM Pharm Ch 36 Anti-virals
| Question | Answer |
|---|---|
| Inhibitor of viral attachment and entry | enfirvutide T-20 |
| This drug used to limit the spread of HIV can cause Guillain-Barre syndrome | enfirvutide |
| These drugs prevent Influenza A from uncoating | amantadine and rimantadine |
| DOC for Infuenza A prophylaxis in nursing homes | rimantadine |
| Nucleoside analogues are used with these 5 viruses | HIV, HBV, HSV, VZV, CMV |
| Selectivity of acyclovir | HSV and VZV thymidine kinases phosphoralates ACV more effectively than human enzymes |
| Acyclovir is used to treat | HSV and VZV |
| More effective but less selective than acyclovir for HSZ and VZV | Famciclovir and pnciclovir |
| This drug comes as an ointment that treats cold-sores cause by HSV | penciclovir |
| Resistance to acyclovir is cause d by | mutations in TK gene or DNA polymerase gene |
| Used to treat serious CMV infections | gancyclovir |
| Drug used to treat CMV retinitis and the drug that needs to be given with it | cidofovir and probenacid |
| Magor side effect of Cidofovir | nephrotoxicity |
| Anti-HIV nucleotide analogue drug given once daily | tenofovir |
| Anti-HBV nucleotide analogue | Adefovir |
| Anti-HIV nucleoside analogue that accumulates in all cells with the least toxicity | Lamivudine 3TC |
| Lamivudine (3TC) can be used to treat what? | HIV and chronic HBV with active replication[ Anti-HIV nucleoside analogue with little side effects and once daily dosing |
| Used to treat serious HSV and CMV infections resistant to acyclovir and gancyclovir | foscarnet |
| Major dose limiting toxicity of foscarnet | renal impairment |
| First anti-HIV drug to be taken once daily | efivirenz |
| HIV Tx, pill containing these 3 drugs approved for once daily treatment | efavirenz, tenofovir, and FTC (emtricitabine) |
| 3 NNRTIs and their main downside to HIV treatment | efevirenz, nevirapin, delavirdine; rapid resistance when given alone |
| Class of drugs that allows HIV viral particles to bud but they are immature and noninfectious | HIV protease inhibitors more –navir’s |
| MOA of oseltamivir and zanamivir | prevents neuraminidase cleavage of influenza virus tethers |
| Used as prophylactic treatment of Influenza A and B | oseltamivir |
| Used intravitreally to treat CMV retinitis | fomivirsen |
| DOC for RSV | ribavirin aerosol |
| Used to treat chronic HCV with addition of an interferon | ribavirin |
| Used to prevent RSV in high risk children | palivizumab |
| Used to treat MS | interferon-β |
| Used to treat HCV, HBV, Kaposi Sarcoma, CML, hairy cell leukemia | Interferon-α |
| Used to treat HPV, basal cell carcinoma, actinic keratosis | imiquimod |
| Used to treat HIV and causes dyslipidemia | any of the –navir’s |
| Drug that can induce HUS | acyclovir |
| Can cause metabolic acidosis and decreased intraocular pressure | cidofovir |
| Treats HSV and can cause seizures | Foscarnet |
| Can cause gastric bleeding and aplastic anemia | interferon-α |
| *DOC for influenza A | *amantadine , rimantadine |
| *DOC for RSV | *Ribavirin |
| DOC for CMV retinitis; not intravitreal | Val/Gancyclovir |
| SE for ganciclovir | Neutro, leuko and thrombocytopenia, anemia |
| HIV antiviral class known to have severe drug interactions by causing inhibition of metabolism | protease inhibitors |
| HIV med used to reduce transmission during birth | zidovudine AZT |
| DOC for herpes and its MOA | Acyclovir and inhibits thymidine kinase (DNA polymerase in book) |
Created by:
csheck
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