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Pharm 34 AntiFungals

LECOM Pharm Ch 34 antifungals

MOA of flucytosine inhibits fungal DNA synthesis. As 5-FU
Flucytosine should be used with caution in these Pts renal Pts
Concaminant use of amphotericin and this drug results in killing of Aspergillus Flucytosine
Treats candidiasis, Cryptococcosis, Chromomycosis Flucytosine
Use this to treat fungal Infx of the skin, hair and nails, and must be given until infected tissues are completely replaced Griseofulvin
Use to treat Trichophyton, Microsporum, or epidermophyton Griseofulvin
Concurrent treatment with barbiturates decreases Gi absorbance Griseofulvin
Anti-fungal medication that induces P450 enzymes griseofulvin
This drug taken orally can exacerbate psoriasis or subacute cutaneous lupes erythematosus Oral terbinafine
MOA of Terbinafine and drug class inhibit squalene epoxidase; allylamines
MOA of Naftifine and drug class inhibits squalene epoxidase; allylamines
MOA of Butenafine and drug class inhibits squalene epoxidase; benzylamine
3 topical drugs more effective against common dermatophytes than azole Terbinafine, Naftifine, butenafine
This is used to treat onychomycosis terbinafine
Squalene epoxidase inhibitor available only in topical cream or gel Naftifine
Terbinafine is not recommended for use in these 3 Pt groups liver and kidney damage, pregnant women
This drug can be used to treat onychomycosis, but has varied oral availability so IV doses are used itraconazole
These anti-fungals inhibit P450 3A4 itraconazole, voriconazole, and fluconazole
5 triazoles Flu-, Itra-, Posa-, Ter-, Vori- conazoles
Ketoconazole cannot be used in Pt’s with achlorhydria, or use of drugs lowering stomache pH ketoconazole
Anti-Fungal agent used for inhibition of all gonadal and adrenal steroids Ketoconazole
MOA of azoles inhibits 14α-sterol demethylase
This imidazole drug also affects fungal fatty acid synthesis miconazole
Pt is allergic to sulfites, what topical azole should not be used ketoconazole
Major adverse effect in itraconazole use hepatotoxicity
Triazole that has potent effects on aspergillus and Zygomycetes posaconazole
Triazole thathas almost 100% Bio-availability orally, is not influenced by stomach pH, and penetrates CSF, sputum, urine and saliva fluconazole
DOC for systemic candidiasis and cryptococcal meningitis fluconazole
DOC for cooccidioidal meningitis fluconazole
In blastomycosis, histoplasmosis, and sporotrichosis which do you use? Itraconazole or fluconazole? itraconazole, more active
Pathway of fluconazole resistant candida P450 enzyme mutations, multidrug efflux transporter proteins
DOC for invasive aspergillosis, fusarium, scedusporium voriconazole
Pt c/o strange symptoms such as photophobia and seeing colored lights after being started on a new drug. What is it? voriconazole
This drug should not be used in renal secondary to increased CNS toxicity of an accumulating metabolite voriconazole
Vaginal suppository inserted at bedtime to treat vaginal candidiasis Terconazole
MOA of Echinocandins non-competatively inhibit β-(1,3)- D-glucan synthesis
Used as primary therapy for esophageal candidiasis and candidemia Caspofungin
Used as salvage therapy for Aspergillus Infx and as empiric therapy for febrile neutropenia caspofungin
These 3 drugs can cause puritis and rash secondary to histamine release caspo-, mica-, anidula-, -fungins
This is used as antifungal prophylaxis for hematopoietic stem cell transplant recipients micafungin
Created by: csheck