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Ch. 17 Continued
Anti-Infective Drugs
| Question | Answer |
|---|---|
| What Drugs are used for Tx of UTI, sinuses, lower resp. tract, GI, skin, bones, joints and Gonorrhea? | QUINOLONES:ciprofloxacin (Cipro), levofloxacin (Levaquin) |
| If pt is allergic to other antibiotics use this durg? | QUINOLONES |
| Before initiating a quinolone...? | C&S tests should be drawn to identify the causative organism. |
| Side effects of quinolones include: | N/V/D, abd pain, colitis, headache,dizzy Crystalluria, Superinfection, Phototoxicity, cartilage or tendon damage. |
| Use caution w/ quinolones and...? | elderly, GI disease, or arteriosclerosis, Strenuous exercise, (Tendon rupture)Seizure disorder. renel impairment |
| A broad-spectrum antibiotic used in Tx of rickets, chlap, Rocky Mtn. Fever, ACNE...? | Tetracyclines |
| Used to treat H. pylori infection? | Tetracyclines |
| Unfortunate sided effect of tetracyclines? Take it at what time of day? | discolored teeth in the young. Cant take if younger than 8yo. b/c of bone retard. Morning |
| Avoid taking________ with tetracyclines? | Antacids, Ca, Mg laxatives, Fe, Zn, Antidearrhea agents kaolin pectin or bismuth. Dairy products, Oral Contraceptives |
| If you dont discard expired drugs, _____ can result form taking outdated drugs. | Nephrotoxicity |
| What durgs are used to treat specific susceptible fungi? | Antifungals |
| What is the antifungal of choice? ppl w/ AIDS | Amphotericin B (IV) |
| Amphotericin B has severe side effects so... pt require...? | close medical supervision (hospitialization) |
| Side effects fo Amphotericin B include?: | Headache, chills, Fever-tachypnea, hypotension. Nephrotoxicity-(BUN, Cretine, Output measured) Hypokalemia |
| lipid based product that increases tolerability of antifungals ? | Abelcet |
| What drug is used to treat candidial infections? (yeast infections) | Fluconazole (Dyflucan) |
| What drug will cancel Fluconazole? | Rifampin- leads to clincal failure of fluconazole |
| Extreme caution w/ fluconazole and ...? | kids <13, preg, nursing, Hepatic or renal disease. Nephrotoxic! |
| What durg is administered PO, Tx of specific fungi causing tinea infections..? (Ringworm) | Griseofulvin |
| Side effects of Griseofulvin include:? | THIRST, headache, hypersensitivity reactions, photosensitivity. |
| Use caution w/ on Griseofulvin? | Kid <2, Preg, Liver dysfunction, Porphyria, Penicillin hypersensitivity |
| Avoid _____ while taking Griseofulvin. | Alcohol, Phenobarbital, coumarin, oral contraseptives |
| This drug is used to Tx (PO), of intestinal candidiasis. Or topically for Tx of Diaper Rash? | Nystatin (Mycostatin) |
| Antituberculosis agents are given for 2 purposes: | 1)Tx asymptomatic infection 2)Tx of active clinical TB & to prevent relapse |
| For asymptomatic TB. Tx consist of ...? How long? | daily isoniazid (INH) alone for 6-12 mths to prevent devel. of disease. |
| Alternate Tx of asymptomatic TB or INH-resistant use these drugs for Tx? | rifampin w/pyrazinamide |
| Tx of clinical TB is challenging for 2 reasons:? | 1)Increasing incidence of TB,high-risk pop. 2)resistant to drugs or imcompletion of 6-24 mth Tx. |
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