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Pharm 14 AEDs

LECOM Pharm Ch 14 AED seizure drugs

4 AEDs that act on Na+ channel inhibition phenytoin, carbamazepine, lamotrigine, valproic acid
AEDs that enhance Na+ channel inhibition are good drugs for partial seizures and secondary generalized seizures
Na+ channel blocker AEDS function in what manner? use dependent manner
MOA of Phenytoin slows channel recover between inactivated to closed
Phenytoin is a major drug choice for what types of seizures? Partial and Tonic-Clonic (secondary generalized) seizures
AED that when used with phenytoin can greatly decrease phenytoin levels carbamazepine
Pt with seizures that takes phenytoin might be switched to this drug if they need medications for other medical problems Carbamazepine
MOA of Carbamazepine slows recovery of Na+ channel from inactivated to closed
3rd line DOC for atypical absence seizures lamotrigine
AEDs that block T-type calcium channels are used for what absence seizures
1st line therapy for uncomplicated absence seizures ethosuxamide
2nd line AED for absence seizures not responding to ethosuxamide valproic acid
Partial seizures not responding to phenytoin or carbamazepine are usually treated with Valproic acid
MOA of Valproic Acid affects Na+ channels, at slightly higher concentration inhibits T-type Ca++ channel, and also stimulates GABA synthesis and inhibits it’s degradation
Pt has a generalized epileptic syndrome with mixed seizure types. DOC? Valproic acid
DOC for idiopathic generalized seizures Valproic acid
MOA: Gabapentin increases GABA but major action is inhibiting HVA Ca++ channels
4th DOC for absence seizures clonazepam
MOA of benzodiazepines increase affinity for GABAa receptors; increase Cl- influx through GABAa receptor
MOA that makes clonazepam special from other benzos inhibit T-type Ca++ channels in the thalamus, “turning off” the reticular nucleus
Benzo’s are used in what mode for seizure Tx used to ablate partial and tonic-clonic seizures
Don’t give phenobarbital with this type of seizure because it might exacerbate it absence seizures
Used in extreme refractory epilepsy b/c can cause fatal aplastic anemia felbamate
Used in ventricular arrhythmias that don’t respond to lidocaine or procainamide Phenytoin
MOA for benzodiazepines increase the FREQUENCY of GABA-mediated chloride ion channel opening
Benzodiazepine that has efficacy against absence seizures and in anxiety states, such as agoraphobia clonazepam
DOC for status epilepticus Diazepam
2 AEDs used for treatment of Bipolar Affective Disorder Carbamazepine, lamotrigine
If Pt is being treated for partial or tonic-clonic seizures with multiple drugs and drops dead, suspect this drug tiagabine
Adjunct therapy for partial seizures that may cause anemia or leukopenia levetiracetam
Created by: csheck