Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Immuno 12 Deficiency
Immuno Ch 12 Acquired and Congenital Immunodeficiency
| Question | Answer |
|---|---|
| B-cell def. : infections seen? | Pyogenic bacteria |
| T-cell def.: infections seen? | viral and intracellular microbes; Virus-associated malignancies |
| 50% of X-linked SCID is caused by mutations to what? | common γ chain |
| common γ chain is involved in binding which ILs? | IL-2, 4, 7, 9, 15 |
| IL-7 does what? | encourages maturation of T-cells |
| What IL is associated with NK cell proliferation? | IL-15 |
| 50% of autosomal SCID is caused by mutations in what? | ADA enzyme |
| What does ADA do? | breaksdown purines |
| Most common syndrome of B-cell maturation block is? | X-linked agammaglobulinemia / Bruton’s agammaglobulinemia |
| Genetic cause of X-linked agammaglobulinemia? | mutation of BtK gene |
| ¼ of Bruton’s Pt’s experience what? | autoimmune disease, mainly arthritis |
| Decrease in all Igs and marked reduction in peripheral mature B-cells. Dx? Genetic cause? | Bruton’s X-linked mutation in BtK |
| Decrease in all T-cells; normal B-cells; Normal or slightly decreased Igs Dx? | DiGeorge Syndrome |
| Extremely high levels of IgM. Dx? What else do you see? Genetic cause? | X-linked hyper-IgM syndrome; absent IgG or IgA; mutation in the CD40Ligand |
| Lack of CD4+ T-cell activation Dx? Mutation? | Bare-lymphocyte syndrome; mutation in MHC II gene |
| Mutation in phagocyte oxidase causes what? | Chronic granulomatous disease. |
| Absent β2-integrin causes what? | defective leukocyte migration; Leukocyte Adhesion Deficiency-1; mutation to CD18 gene |
| Absent E- or P-selectin | Leukocyte Adhesion Deficiency-2 |
| Eczema, reduced platelets, immunodeficient Pt. Dx? | Wiskott-Aldrich syndrome |
| Gait abnormality, vascular malformations, immunodeficient Pt. Dx? | Ataxia-telangiectasia |
| Recurrent bacterial infxs, phagocytes and NK cells affected. Dx? And cause? | Chediak-Higashi syndrome; lysosomal granule dysfunction. |
| HIV binds what on cells? And what cells? | uses gp120-> CD4(tcell) +CXCR4(tcell) or CCR5(macrophage) |
| Mutation of this allows individuals to remain disease free for years after HIV infection | CCR5 |
| 2 most common cancers in HIV and virus associated | B-cell lymphoma/ EBV; Kaposi;s sarcoma/ herpesvirus |
Created by:
csheck
Popular Science sets