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NURS 572 Exam 2 - 2
Exam 2, part 2 growth factors, coag
| Question | Answer |
|---|---|
| hematopoietic growth factors treat for | RBC, WBC |
| thrombopoietic growth factors treat for | platelets |
| how must all hematopoietic factors be admin | parenterally |
| epoetin-alpha MOA | recomb DNA --> RBC production. Need essential Fe, Folic Acit, Vit B12 |
| indications for epoetin-alpha | chronic renal failure, HIV +, chemorx pts, anemic pts facing surgery |
| epoetin-alpha ADRs | HTN (increased Hgb) --> MI, CVA, HF very rare autoimmune red cell aplasia |
| epoetin-alpha monitoring | Hgb should be 10-12 g/dL, monitor bp q 4. May require anti-HTN med |
| darbepoetin-alpha | modified epoetin for double half life of 48h |
| methoxypolyethylene glycol epoetin beta | modified epoetin lasts much longer, q2 week admin |
| filgrastim-G-CSF full name | filgrastim granulocyte colony stimulating factor |
| filgrastim-G-CSF indications | severe, chronic neutropenia -->to elevate neutrophil counts in cancer pts EXCEPT myeloid cancers |
| filgrastim - G - CSF ADRs | bone pain, leukocytosis (increases to 100,000) |
| filgrastim - G - CSF monitoring | monitor CBC, temp, infection, bone pain |
| pegfilgrastim | pegylated with polyethylene glycol to increase half life, otherwise same as figrastim |
| sargramostin GM-CSF full name | granulocyte + marcrophage/monocyte colony stimulating factor |
| sargramostin GM CSF indications | bone marrow transplant pts, to increase neutrophils, macrophages/monocytes |
| sargramostin GM CSF ADRs | diarrhea, weakness, rash, bone pain, leukocytosis and/or thrombocytosis |
| oprelvekin IL-11 full name | oprelvekin interleukin -11 |
| oprelvekin IL-11 MOA | thrombopoietic growth factor stimulates megakaryocytes and maturation |
| oprelvekin IL-11 indications | for myelosuppresive chemorx to minimize thrombocytopenia, decreasing the need for platelet transfusion |
| oprelvekin IL-11 ADRs #1 | Na/fluid retention --> 15% increase in plasma volume --> peripheral edema --> HF |
| oprelvekin IL-11 ADRs #2 | cardiac dysrthythmias, blurred vision, papilledema, rarely death |
Created by:
lorrelaws
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