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NURS 572 - 74
Ch 74 bone mineralization drill
| Question | Answer |
|---|---|
| Side effect of calicium, Vit D products | constipation |
| What class of drugs cause decreased absorption of Vit D and calcium products | corticosteroids |
| Oral forms of calcium | Calcium salts usually calcium carbonate which has highest percentage of calcium, cheapest |
| Other forms of calcium salts - Ca | chloride, gluconate, glucepate, lactate, acetate, citrate |
| What is the oral form of calcium | calcium glubionate |
| What is the inactive form of Vitamin D | cholecalciferol |
| Which activated Vitamin D is given po or injection | calcitriol |
| Which activated Vitamin D is given po only and synthetic | doxercalciferol |
| Which activated Vitamin D is given injection only and is synthetic | paricalcitol |
| What is the MOA of bisphosphonates | very poor bioavailability into bone where it decreases osteoclast activity |
| Name 3 bisphosphonates | alendronate, risedronate, ibandronate |
| Which bisphosphonates are given either daily or weekly | alendronate, risendronate |
| Which bisphosphonate is given either daily or monthly | ibandronate |
| What SERM is commonly used for osteoporosis and may also protect against estrogen-receptor-positive breast cancer | raloxifine |
| What is the MOA of calcitonin | major role to inhibit osteoclasts--> decreased bone resorption |
| What is calcitonin used for | only drug to TREAT (not prevent) osteoporosis |
| What is an unusual ADR for some calcitonin long-term patients | they can develop antibodies to this product |
| What is the only drug to increase bone formation | teriparatide |
| How does teriparatide increase bone formation | it is a recombinant form of PTH. It increases osteoblast activity > osteoclast activity with net effect of increased bone formation |
| What drug is a calcimemetic | cinacalet |
| What is cinacalcet's MOA | increases sensitivity of calcium sensing cells in the parathyroid --> negative feedback to decrease PTH secretion at lower levels of Calcium than usual |
| what is cinacalcet given for | hypercalcemia (keeps calcium on the bone by increasing PTH receptor sensitivity) |