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BioChem Eicosanoids

LECOM Biochem Eicosanoids Ch 35

Cyclo-oxegenase pathway leads to creation of prostaglandins and thromboxanes
Lipoxegenase pathway leads to creation of leukotrienes, HETEs and lipoxins
Cytochrome P450 pathway leads to creation of epoxides, HETEs and diHETEs
First 3 precursors in the COX system AA->PGG2->PGH2
Prostacyclin Abreviation? Where created? PGI2 and vascular endothelium
Prostaglandins all vasodilatem increase cAMP, and decrease: platelet and leuk agg., IL-1/2 except? PGF2a
PGF2a causes vasoconstriction, bronchoconstriction, smooth muscle contraction
TXA3 causes less______ than TXA2 platelet aggregation
3 carbons lipoxygenases act on 5, 12 and 15
5- 12- and 15- lipoxygenase specific cells 5- PMN leuks, 12- platelets, 15- eosinophils
LTB4 causes increase in vascular permeability, T-cell prolif, Leuk agg, INF-γ, IL-1/2
LTC4 and LTD4 can increased bronchoconstriction, vascular permeability, and IFN-γ
These levels, measured in urine, correlate to levels of oxidative stress Isoprostanes
3 neuro diseases that cause increased oxidative stress Alzheimers, Parkinsons, ALS
These activate cAMP-protein kinase A system PGD, PGE, PGI
These increase intracellular calcium PGF2a, TXA2, endoperoxides, and leukotrienes
Created by: csheck