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N201: Test II
Vocabulary
| Question | Answer |
|---|---|
| Tardative dyskinsia | Involuntary movement of jaw - call doctor immediately or could become permanent |
| CTZ | Chemoreceptor trigger zone |
| Serotonin Agents | Ondanestron (Zofran) |
| Serotonin Action | Blocks the serotonin receptor in our brain that makes us feel nauseous when it's stimulated |
| Metoclopramide (Reglan) | Dopamine & Prokinetic |
| Dopamine Antagonists | Prochlorperazine (Compazine) Promethazine (Phenergan) Metoclopramide (Reglan) |
| Dopamine Action | Blocks the dopamin receptor in our brain that makes us feel nauseous when it's stimulated |
| Ondanestron | Zofran |
| Metoclopramide | Reglan |
| Promethazine | Phenergan |
| Prochlorperazine | Compazine |
| Prokinetic | Metoclopramide (Reglan) |
| Prokinetic Action | Dopamine blocker Increase tone of lower esophageal sphincter Increase peristalsis |
| Serotonin Admin | PO 30 - 40 mins. before Surgery or expected nausea |
| Serotonin Indications | Nausea r/t pregnancy, chemo, cancer |
| Serotonin Side Effects | Headache, Dizziness, Diarrhea |
| Serotonin Teaching | No driving bc sedation |
| Dopamine Indications | Prevents Nausea |
| Dopamine Admin | PO, IV (slow-over 15 mins.), Rectal, No IV Push |
| Dopamine Side Effects | Muscle spasms, tremors, rigidity Hypotension Sedation Dry mouth, urinary retention, constipation |
| Dopamine Teaching | Encourage fluids Make Pt. aware of side effects |
| Prokinetic Indications | Nausea, Vomitting, Pt's w/reflux (moves things through quickly) |
| Prokinetic Admin | IV or PO, usually 30 mins before meals |
| Prokinetic Side Effects | Sedation, diarrhea, dry mouth, Tardative dyskinesia |
| Prokinetic Teaching | No alcohol or driving bc of sedation Monitor BP & hypotension |
| Antihistamines | Dimenhydrinate (Dramamine) |
| Dimenhydrinate | Dramamine |
| Antihistamine Action | Blocks histamine receptors in the inner ear and CTZ - Prevents Motion Sickness |
| Antihistamine Indications | Motion sickness |
| Antihistamine Admin | PO, IV, IM, Rectal Give 30 mins prior to activity that causes sickness |
| Antihistamine Side Effects | Sedation, Drowsiness, Dizziness, Dry mouth, constipation, Urinary retention |
| Antihistamine Teaching | Teach about side effects |
| Antiemetics | Seotonin Antagonists Dopamine Antagonists Prokinetic Antihistamines |
| Seotonin Antagonists Dopamine Antagonists Prokinetic Antihistamines | Antiemetics |
| Histamine2 Receptor Agents | Cimetidine (Tagamet) Famotidine (Pepcid) Ranitidine (Zantac) |
| Histamine2 Receptor Agents Action | Block histamine receptors in stomach to decrease acid in stomach (doesn't prevent reflux but increases pH) |
| Histamine2 Receptor Agents Indications | Reflux, Gastic & duodenum ulcers |
| Histamine2 Receptor Agents Admin | Admin w/or w/o food, don't admin antacids w/in 1 hr. of giving antagonist (effects absorption rate) IV must be given slowly or can cause bradycardia |
| Histamine2 Receptor Agents Side Effects | Nausea, vomiting, diarrhea, constipation Decreased WBC's (long term use) Tagamet: Seizures, Lower labido, Lethargy |
| Histamine2 Receptor Agents Teaching | Antacids affect absorption rate of Antagonist, Smoking also interferes with absorption |
| Cimetidine | Tagamet |
| Ranitidine | Zantac |
| Famotidine | Pepcid |
| Proton Pump Inhibitors (PPIs) | Omeprazole (Prilosec) Lansoprazole (Prevacid) Pantoprazole (Protonix) Esomeprazole (Nexium) |
| PPI Action | Decreases the acids in the stomach |
| PPI Indications | Reflux, duodenum & gastic ulcers |
| PPI Admin | Empty stomach, usually 1x daily before breakfast |
| PPI Side Effects | Nausea, vomiting, diarrhea Long term use = bone loss |
| PPI Teaching | Antacids do not affect absorption ^ Vit D ^ Ca+ ^ Exercise |
| Omeprazole | Prilosec |
| Lansoprazole | Prevacid |
| Pantoprazole | Protonix |
| Esomeprazole | Nexium |
| Mucosal Protectants | Sucralfate (Carafate) |
| Sucralfate | Carafate |
| Mucosal Protectants Action | Creates gel to coat stomach (good w/pt's already have ulcer) |
| Mucosal Protectants Indications | Pt.'s w/ Ulcers |
| Mucosal Protectants Admin | Empty stomach - wait 2hrs before/after meals or other meds - affects absorption |
| Mucosal Protectants Side Effects | Constipation, nausea, diarrhea, dyspepsia |
| Mucosal Protectants Teaching | Teach pt how to take |
| Antacids | Aluminum hydroxide (Amphojel) Calcium carbonate (Tums) Magnesium hydroxide (Milk of Magnesia) |
| Aluminum hydroxide | Amphojel |
| Calcium carbonate | Tums |
| Magnesium hydroxide | Milk of Magnesia |
| Aluminum hydroxide Action | Neutralize gastric acid |
| Aluminum hydroxide Indications | Ulcers and reflux |
| Aluminum hydroxide Admin | PO |
| Aluminum hydroxide Side Effects | Amphojel & Tums: Constipation Milk of Magnesia: Diarrhea |
| Aluminum hydroxide Teaching | Know what other medications are being taken |
| Decreased Blood flow + Increased stomach acid = | Perfect environment for an ulcer |
| Prostaglandin E Analogs | Misoprostol (Cytotec) |
| Misoprostol | Cytotec |
| Prostaglandin E Analogs Action | Works to increase pH, protect against ulcer, allow adequate blood flow to the gastric wall |
| Prostaglandin E Analogs Indications | Prevents gastric ulcers from long-term NSAID use |
| Prostaglandin E Analogs Admin | Take w/meals while taking NSAID |
| Prostaglandin E Analogs Side Effects | Diarrhea, Ab pain, nausea Women: uterine cramps, spotting |
| Prostaglandin E Analogs Teaching | Do not take if pregnant - spontaneous abortion |
| What drug can cause a spontaneous abortion in women if taken during pregnancy? | Misoprostol |
| Cancer of Oral Cavity Risk Factors | Alcohol/smoking Greater in Males >50yrs |
| Cancer of Oral Cavity Pathophysiology | Lips, Tongue, Floor of mouth |
| Cancer of Oral Cavity Clin. Manifestations | Painless lesion that doesn't heal |
| Cancer of Oral Cavity Diagnostic Tests | Biopsy to confirm |
| Cancer of Oral Cavity Treatment | Depends on type/extent |
| Cancer of Oral Cavity #1 concern | Airway |
| A stroke is the | 3rd leading cause of death in USA |
| Up to 80% of strokes are | preventable |
| Strokes are the leading cause of | long-term disability |
| _______ are more likely to have a stroke. | Men |
| _______ are more likely to die from a stroke. | Women |
| Cerebrovascular Disorder | Any interruption of blood supply to brain causing CNS Functional abnormality |
| Stroke | O2 supply to the brain is disrupted |
| Stroke has 4x higher incidence in | left hemi-sphere |
| "STR" | Can a person... Speak simple sentence? Talk? Raise both arms? |
| "F A S T" | Facial Arms Speech Time |
| Neuroplasticity | Neuron's ability to rearrange connections |
| Brain adaption | brain saturated w/blood or deprived of O2 = find alt. pathways |
| Transient Ishemic Attack (TIA's) | Cerebral ischemic event lasting < 24 hrs May even last just a few minutes No permanent neurological chgs. |
| Evolving Stroke | Worsening of deficits over minutes Suggests widening area of ischemia |
| Completed Stroke | Acute cerebral ischemic event w/deficits |
| #1 risk factor for stroke | Hypertension |
| TIA aka | "warning strokes" |
| Blood clot temporarily clogs artery so part of brain doesn't get blood it needs | TIA |
| S/S of TIA | Similar to stroke, usually last 1 or 2 mins. |
| Ischemic Stroke | Obstruction of cerebral blood flow |
| 88% of all strokes are | Ischemic Stroke |
| "Worst headache of my life" | Subarachnoid hemorrhage |
| Receptive Aphasia | Person doesn't know what's going on |
| Expressive Aphasia | Person knows what's going on, but can't express |
| Broca's Area located in | Left hemisphere |
| Controls tongue, lips, vocal cords & ability to phonate (form words) | Broca's Area |
| Global Aphasia | Expressive & receptive aphasia |
| Dysphagia | Difficulty swallowing |
| Dysarthia | Impaired speech |
| Ataxia | Gait disturbance |
| Nystagmus | Rapid Eye Movements |
| Hemianesthesia | Pain on one half of body that doesn't completely register |
| Wernicke's Area | Can be in whichever hemisphere is dominant for pt. |
| Recalls, recognizes & interprets words & other sounds in the process of "phonating" | Wernicke's Area |
| Dmg. to Wernicke's Area (Temporal lobe of dominant hemisphere) | Inability to comprehend spoken or written words |
| If a Pt. is newly diagnosed with Afib, do TEE test to see if | There are clots behind the heart |
| Trans-esophageal echocardiogram | TEE test |
| Tissue Plasminogen Activator (tPA) | Time of onset is known and < 3 hrs |
| Pt not a candidate for tPA if | Pt is rcvg IV Heparin |
| Angioplasty | Any endovascular procedure to reopen narrowed blood vessels & restore forward blood flow |
| Atherectomy | Opens occluded, scarred or calcified vessels by removing atherosclerotic plaques with rapidly rotating drills |
| Balloon angioplasty | Relies on the inflation of high-pressure balloons within blocked arteries to force open |
| Laser & radiofrequency waves | Vaporize or ablate atheroscleroptic plaques |
| Endovascular stents | Hold vessels open with expandable lattices inserted across narrowed section of the artery |
| Cerebral Angioplasty | Coils surgically placed in cerebral vascular malformations to assure patency and prevent rupture (Aneurysm) |
| Hemorrhagic Strokes | Vessel ruptures & bleeds into brain or spaces around brain |
| Intracerebral Hemorrhage | Always hypertension related |
| Craniectomy | Removal of part of the brain |
| Craniotomy | Redirection - keep from getting to brain stem |
| Subarachnoid Hemorrhage | Bleeding into subarachnoid space |
| Arteriovenous Malformation | A tangle of blood vessels in the brain or on the surface of brain that bypasses norm brain tissue and diverts blood from arteries to the veins |
| Mandibular Fractures Clin. Manifestations | Dull ache -> throbbing pain Restricted jaw movement |
| Mandibular Fractures Diagnostic | X-ray or MRI |
| Mandibular Fractures Treatment | Rigid plate fixation Bone grafting |
| Mandibular Fractures Nurse Mngmnt. | #1 Airway #2 Nutrition |
| Absent/ineffective peristalsis of distal esophagus Failure of esophageal sphincter to relax in response to swallowing | Achalasia |
| Achalasia | Food cannot get into the stomach |
| Achalasia Diet | Small frequent meals/soft/encourage fluids |
| Achalasia Meds | Ca+ channel blockers relax sphincters |
| Achalasia Pneumatic dilation | Balloon to try and open sphincter up |
| Achalasia Esophagomyotomy | Enter esophagus & cut muscle fibers |
| 90% of Hiatal Hernias are | Sliding esophageal hernias |
| sliding Hernia Manifestations | Heartburn Regurgitation Dysphasia Belching Reflux* |
| Reflux Occurs w/sliding hernia because | Sphincter is NOT intact - food easily regurgitates into esophagus. |
| Paraesophageal manifestations | Sense of fullness after eating Indigestion May be a symptomatic |
| The sphincter in a paraesophageal hernia | Is still intact. |
| Hiatal hernia complications | Strangulation |
| Gastroesophageal Reflux Disease (GERD) | Backflow of gastric contents into esophagus |
| Avoid these if you have GERD | High-fat diet Caffeine, tobacco, alcohol, spearmint, peppermint, carbonated bevs Eating 2 hrs before bed Tight clothing |
| Meds for GERD | Antacids Histamine Receptor Blockers PPIs Prokinetic Agents |
| Treatment of GERD | Nissen fundoplication |
| Nissen fundoplication | Surgery to wrap stomach around esophagus = No reflux |
| Barrett's Esophagus | Chgs cells in esophagus bc constant burning of lining from reflux -> pre-cancerous condition |
| S/S Barrett's Esophagus | Same as GERD -> ppl usually don't know it's happening |
| Barrett's Esophagus Diagnosis | Endoscopy |
| Barrett's Esophagus Treatment | Minor cell chgs Photodynamic therapy (PDT) Prohylactic esophagectomy |
| Photodynamic therapy (PDT) | Take out piece of esophagus & replace w/jejunum or part of stomach |
| Risk factors for Cancer of Esophagus | Barrett's Alcohol Tobacco 3x more common in men |
| Cancer of Esophagus Mgmnt | Radiation Chemotherapy Surgery (Esophagectomy) |
| Gastritis | Inflamation of the stomach |
| Gastritis Patho | Lining can become swollen & ulcerate Can cause perferation of lining = hemorrhage |
| Acute Gastritis Clin. Manifest | Abdominal discomfort Nausea Vomiting |
| Chronic Gastritis Clin. Manifest | Abdominal discomfort Nausea Vomiting Heart burn Pain |
| Chronic Gastritis | Find the trigger |
| The most common location for ulcers is | the duodenum. |
| Peptic Ulcer Disease | Increased acid & decreased mucus allow acid to erode mucosal wall |
| Peptic Ulcer Disease occurs in the | Stomach Pylorus Duodenum Esophagus |
| Increase gastric acid production | Caffeine Smoking Alcohol Stress |
| H. pylori | Bact will burrow into the lining allowing acid in to create an ulcer |
| H. pylori requires | 2 different Ab's to cure |
| Intractable Ulcers | Incurable Ulcers - (perform Vagotomy) |
| Vagotomy | Cut Vagus nerve to decrease production of stomach acid - (incurable ulcers) |
| Antrectomy - Billroth I | Take out lower portion of stomach to decrease stomach acid |
| "Coffee Grounds" in stomach/vomit | Hemorrhage |
| Peritinitis | Stomach leak out causing bacterial infection - sepsis |
| Perforation complications can lead to | Peritinitis |
| Any leakage into the abdominal cavity... | Requires Ab's |
| Weight indications for surgery | BMI >40 or over 100 lbs overweight |
| 3 Categories of Bariatric Procedures | Malabsorptive Restrictive Combined Malabsorptive & Restrictive |
| Rstrictive Surgery: | Reduces food intake Decrease in appetite Early satiety Control of stoma Craving control (Ghrelin) |
| Laparoscopic Gastric Banding | Inflatable silicone band completely around upper portion of stomach |
| Vertical Sleeve Gastrectomy (VSG) | 85% of stomach removed - shaped like small banana |
| Gastric Bypass | Limits size of stomach and bypasses some of the small intestine |
| Secretory Diarrhea | Bowel doesn't reabsorb water - it excretes water |
| Osmotic Diarrhea | Pulling of water into the bowel |
| Infectious Diarrhea | C-diff |
| Antidiarrheals | Loperamide (Imodium) Diphenoxylate (Lomotil) |
| Loperamide | Imodium |
| Diphenoxylate | Lomotil |
| Constipation | Abnormal infrequency or irregularity of defications Abnormal hardening of stools Retention of stool in rectum |
| Chronic Constipation | <3 bowel movements/week for 12 weeks in a 12 month period |
| Bulk forming Laxatives | Psyllium (Metamucil) Methylcellulose (Citrucel) |
| Psyllium | Metamucil |
| Methylcellulose | Citrucel |
| Bulk forming Laxative Action | Promotes large soft stools by absorbing water into the intestines Stimulates peristalsis |
| Lubricant Laxatives | Mineral oil Glycerin suppository |
| Lubricant Laxative Action | Softens fecal matter and lubricates intestinal tract |
| Stimulant Laxatives | Bisacodyl (Dulcolax) Senna (Senokot) |
| Bisacodyl | Dulcolax |
| Senna | Senokot |
| Stimulant Laxative Action | Irritates colonic epithelium by stimulating sensory nerve ending and increasing peristalsis |
| Fecal softener Laxatives | Docusate (Colace) |
| Docusate | Colace |
| Fecal softener Laxative Action | Promotes incorporation of water into the stool resulting in softer fecal mass More of daily treatment 1-5 days to take effect |
| Osmotic Agent Laxatives | Polyethylene glycol and electrolytes |
| Osmotic Agent Laxative Action | Rapidly pulls H2O into colon -> diarrhea out |
| Common Hernia Locations | Inguinal Femoral Incisional Umbilical |
| Volvulus - Mech. Obstruction | Twisting of the bowel - caused by congenital abnormality |
| Intussusception - Mech. Obstruction | Tunneling of bowel (folds in on itself) |
| Paralytic illeus - Functional obstruction | No blockage, lack of movement (caused by surgery) |
| Diverticulum | Sac like pouches -> sigmoid colon, usually |
| Diverticulosis | Multiple Diverticulum |
| Diverticulitis | Food or infection stuck in diverticula & cause inflammation |
| Diverticular Disease | Submucosal layers of the colon herniate through the muscular wall |
| Diverticular Disease Complications | Peritonitis Abscess formation Fistulas Bleeding |
| End-to-end anastomosis | Cut out bad bowel & reconnect |
| Appendicitis | Food or infection gets lodged in the appendix |
| Diarrhea is common in | Chrohn's Disease |
| In Chrohn's Disease, constipation is | Occasional |
| Blood in stool in Chrohn's Disease is | Occult Common |
| Abdominal pain in Chrohn's Disease is | Typically mid-abdomen and right lower quadrant pain |
| Fever in Chrohn's Disease is | Common |
| Weight loss/growth failure in Chrohn's Disease is | Common May occur for many months to years before diagnosis |
| Perianal disease in Chrohn's Disease is | Common for: Fistula/fissures Abscesses/skin tags |
| Diarrhea in Ulcerative Colitis is | Common, often with urgency |
| Constipation in Ulcerative Colitis is | Rare without obstruction |
| Blood in stool in Ulcerative Colitis is | Very common |
| Abdominal pain in Ulcerative Colitis is | Cramping pain, often with stools |
| Fever in Ulcerative Colitis is | Rare |
| Weight loss/growth failure in Ulcerative Colitis is | Rare |
| It is rare to have Perianal disease with | Ulcerative Colitis |
| Chrohn's disease... | often recurs after surgery |
| Ulcerative colitis... | is curable with a colectomy |
| Right hemisphere | right now, present pictures, sound, sight, smell |
| Left hemisphere | past, future associate present with past to prepare future Broca's area - speech center |
| Broca's area | Speech center, left hemisphere |
| Magnetic Resonance Imaging | MRI |
| Second largest part of brain Balance and coordination, assists in controlling body movements | Cerebellum |
| Largest most advanced part of brain higher intellect, speech, movement, emotion, and integration or sensory stimuli | Cerbrum |
| Handles automatic functions Respiration, heart rate, BP, arousal, wakefulness & attention | Brain Stem |
| Artistic, creative, intuitive | Right hemisphere |
| Logic, reasoning, linear | Left hemisphere |
| Cerebral edema | any swelling of the brain |
| Frontal lobes | Voluntary muscle movements |
| Parietal lobes | regulate taste and touch |
| Temporal lobes | regulate hearing & smell |
| Occipital lobes | regulate vision |
| 3 ways Neurological Changes may affect the body | Structural Metabolic Drug Related |
| Cardiovascular Respiratory Infection | 3 ways Neurological Changes may affect the body |
| AEIOU Tips = A | acidosis, alcohol |
| AEIOU Tips = E | epilepsy |
| AEIOU Tips = I | infection |
| AEIOU Tips = O | overdose |
| AEIOU Tips = U | uremia |
| AEIOU Tips = T | trauma |
| AEIOU Tips = i | insulin |
| AEIOU Tips = p | psychogenic |
| AEIOU Tips = s | stroke |
| Often, the first sign that a neurological event is already in progress | Restlessness |
| Progressive dilation of pupils | increasing ICP |
| Fixed pupils | very serious injury at midbrain or lower |
| Corneal reflex is | unilateral or absent in coma |
| Cheyne-stokes respirations mean that | lesion or injury is deep within cerebral hemispheres (death is usually imminent) |
| CT Scan, MRI | Show displacement of brain structures |
| EEG | studies brain's electrical activity |
| Cerebral angiography | detects aneurysms, occluded vessels & tumors w/in cerebral arts/veins |
| Transcranial Doppler | assesses cerebral blood flow |
| Lumbar puncture | CSF detects blood, WBCs, meningitis |
| The 2 essential things the brain needs to survive are | O2 & glucose |
| Brain | 80% of skull's contents |
| CSF | 10% of skull's contents |
| Blood | 10% of skull's contents |
| Hypercapnia | Increased cerebral vasodilation then increased blood flow then increased ICP |
| Hypoxemia | Cerebral vasodilation, which raises ICP |
| Vasodilator drugs | increase cerebral blood flow -> temp increased ICP (Nitroglycerin) |
| Cerebral Perfusion Pressure | Pressure needed to perfuse brain cells |
| Normal CPP | 70-100 mm Hg |
| CPP < 50 | irreversible brain dmg |