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patho and pharm prin

generally applicable to patho and pharm subjects

QuestionAnswer
what is the most important lab values to monitor generally speaking? electrolyte
what is the most urgent electrolyte to pay attention to? hyperkalemia (potassium)
Disulfiram-like effect flushing, sweating, tachycardia, headache, nausea, vomiting, weakness
Stevens-Johnson syndrome Fever, rash, and bullae on skin and mucous membranes, widespread sloughing of skin and mucous membranes, potential death due to infection from loss of skin integrity
Drugs that cause constipation aluminum and calcium antacids, sucralfate, H2 receptor antagonists, anticholinergics, and those with anticholinergic effects
Drugs that cause diarrhea some antibiotics, magnesium antacids, misoprostol, proton pump inhibitors
Drugs that cause drowsiness H2 receptor antagonists, proton pump inhibitors; alcohol, NSAIDS, antihistamines, anticonvulsants, psychotropic, things with central nervous system effects
extrapyramidal symptoms extreme restlessness, involuntary movements, and uncontrollable speech
effects of anticholinergics dry mouth, blurred vision, drowsiness, sweating
Drugs metabolized by CYP450 enzymes diazepam and antianxiety drugs; phenytoin (anticonvulsant); warfarin
natural products that can cause bleeding feverfew, garlic, ginger, ginkgo, others
other drugs that can cause bleeding aspirin, NSAIDs, penicillins, corticosteroids, warfarin
Factors that promote thrombus formation virchow's triad: alterations in normal blood flow, injuries to vascular endothelium, alterations in constitution of blood (hypercoagulability)
s/s of systemic anaphylaxis difficulty breathing-wheezing; severe hypotension, tachycardia, hives/itch; swelling of mucous membranes
suppress hepatic CYP450 enzymes grapefruit juice, cimetidine, erythromycin, omeprazole
induce hepatic CYP450 enzymes Rifampin, St. John’s Wort, phenytoin, char-broiled meats, smoking.
Drugs that decrease K+ glucocorticoids, K+ wasting diuretics, licorice
phases of tissue healing inflammation, reconstructive (proliferative), maturation (remodeling)
inflammation phase of tissue healing toxins diluted, cellular debris and microorganisms phagocytized, cytokines and growth factors secreted
reconstructive phase of tissue healing collagen matrix and granulation tissue produced, epithelium covers surface, new blood vessels develop
maturation phase of tissue healing collagen in the area is reorganized over extended period of time
Created by: hezasan