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TL Alpha Blockers

Alpha adrenergic blockers

QuestionAnswer
How do alpha blockers work? they interrupt the actions of the catecholamines epinephrine and norepinephrine at the receptor sites
What kind of actions would result from the use of an alpha blocker? relaxation of blood vessel smooth muscle – vasodilation and decreased blood pressure
What group of letters is common to the name ending of Alpha blockers? Osin or Zosin
Say terazosin toe raise a sin
Say tamsulosin tam sue low sin
Say Alfuzosin Al few zoe sin
Say Phenoxybenzamine fin oxy bens uh mean
Say Phentolamine fin toll uh mean
Say Prazosin Praise sews zin
Say Doxazosin Docks says sews zin
Name some common alpha blockers (AEPPPDTT). Alfuzosin, ergoloid mesylates, phenoxybenzamine, phentolamine, prazosin, doxazosin, terazosin, tamulosin
Explain the weird thing about the action of Ergotamine. Ergotamine (ER-Gotta-Mean) is a mixed alpha agoninst/antagonist – it works as an alpha blocker at high doses
How does absorption of alpha blockers by mouth compare with sublingual administration? alpha blockers PO are absorbed erratically. Sublingual alpha blockers are absorbed more rapidly and completely.
Explain the 2 ways in which alpha blockers work. they can block the synthesis, storage, release, and reuptake of norepinephrine by neurons or they can antagonize epinephrine, norepinephrine, or adrenergic drugs at receptor sites
Describe how the actions of alpha blockers affect blood vessels and blood pressure. Alpha blockers occupy alpha receptor sites in blood vessels smooth muscles which prevents stimulation by catecholamines resulting in vasodilation, increased blood flow, and decreased peripheral vascular resistance
Define sympathetic tone. the state of partial constriction of blood vessels before an alpha blocker is administered
Explain why standing up can cause a sudden drop in blood pressure if the client is taking an alpha blocker. Why doesn’t the same thing happen when the client is laying down? sympathetic tone is low when lying, greater when standing. Since alpha blockers block the effect o epinephrine, if not much epinephrine is exerting effect then the administration of alpha blockers doesn’t create much change.
What 3 actions of alpha blockers that make them therapeutically useful? they relax smooth muscles and cause blood vessels to dilate, increase blood flow to skin and organs, and reduce blood pressure
Name four conditions that alpha blockers are useful for. benign prostatic hyperplasia, hypertension, peripheral vascular disorders with lack of peripheral blood flow like Raynaud’s, acrocyanosis, and frostbite; pheochromcytoma (super hypertension due to tumor)
Considering the action of alpha blockers what do you expect would be the most common adverse effect? hypotension
Name two drugs that if taken in combination with ergotamine would increase its effects? Caffeine and macrolide antibiotics
What drug if combined with ergotamine would cause increased pressor (rising blood pressure) effect? dopamine
What’s the potential adverse effect of mixing nitroglycerine and alpha blockers? hypotension from excessive dilation of blood vessels
What are the potential adverse effects of alpha blockers? orthostatic hypotension, rebound hypertension, bradycardia, tachycardia, edema, difficulty breathing, light headedness, flushing, arrhythmias, angina, heart attack, spasm of blood vessels in the brain, shock-like state