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bi humoral vs cell m

grcc bi240 Humoral vs Cell mediated immunity

Stem cells Humoral and cell-mediated
Humoral immunity produces B Lymphocytes, clone memory cells, plasma cells and antibodies
Cell mediated T lymphocytes, Helper T cells, cytoxic T cells, memory T cells, Suppressor T cells
Lymphoblasts bone marrow stem cells
what do lymphoblast do? they produce lymphocytes which mature into immunocompetent cells that recognize and react with antigens in body
Two groups of lymphocytes determine type of immunity initiated T-lymphocytes (cell-mediated) and B-lymphocytes (humoral)
B- lymphocytes (B Cells) produce Humoral immunity
Where are lymphocytes produce and mature? produced in the bone marrow then migrate to spleen and lymphatic tissue.
After lymphocytes are in spleen and lymphatic tissue they undergoe clonal diversification & clonal selection
Colonal diversification and clonal selection produce memory cells and plasma cells which are antibody's secreted into circulation and mucosal surfaces
Humoral immunity is activated when there is exposure to antigen & T lymphocytes results in production of antibodies/immunoglobulins & memory B cells.
Humoral immunity acts against bacteria and viruses.
Cell mediated immunity is produced from T-Lymphocytes (T-Cells)
t-lymphocytes are produced in bone marrow and migrate to thymus where they mature and eventually migrate to lymph nodes
T-lymphocytes act against Virus infected cells, fungal & protozoal infections, cancer cells and foreign cells
What are the subgroups of T Cells helper T cells, cytoxic T cells, memory T cells, suppressor T cells
Cell mediated immunity develops when T lymphocytes recognize antigens on the surface of target cells and destroy them directly.
After T-cells directly destroy antigens they reproduce an army and activate other T and B lymphocytes.
Tolerance cell mediated immunity Immune system targets foreign cells/material and ignores host tissue= it is able to distinguish self from non self.
Helper t cells CD4 regulates the immune response (CD4 is targeted by HIV) ratio count s/b 2;1...if 1:1 then infection
cytoxic T cell CD8 cell Killer T cells are receptors bind, and release damaging chemicals/enzymes and helps to destroy antigens, cancer cells, virus infected cells.
memory T cells remain in lymph nodes for years, activate response again if samd invader returns.
Suppressor T cell Suppresses B cell activity.
Antibodies (immunoglobulins) protein produced in plasma cells as part of humoral response
Antibodies bind to specific matching antigen to form immune complex
Antibodies (immunoglobulins)enchance phagocytosis by macrophages
Antibodies (immunoglobulins) stimulates inflammation = mast cell degranulation
Antibodies (immunoglobulins)protect host from bacterial toxins by binding to the toxins to neutralize their biological effects.
Antibodies (immunoglobulins) inactivate antigen via neutralization, agglutination, precipitation, osponization
Neutralization masks or coats dangerous part of bacterial toxin or virus.
agglutination clumping of cells with bound antigens
precipitation soluble antigens come out of solution
osponization antibodies bound to antigen enhance phagocytosis
Antibodies (immunoglobulins)activates the complement system which leads to cell lysis and death
Antibodies (immunoglobulins) have different structures
There are how many 5 classes of Antibodies (immunoglobulins) IgG, IgM, IgA, IgE, IgD
IgG Most common in blood and increases in number after immunization.
IgM bound to B cells in blood, FIRST to increase when first exposed.
Challenges antigen involved in blood incompatibility IgM
IgA Found in Mucosal & glandular secretions (blood, tears, saliva, respiratory secretions
Passive form of protection breast milk/colostrum provided newborns protection IgA
When linked to an allergen to allergic response IgE
Attached to B cells, the antigen receptor on lymphocytes prior to immunication IgD
Primary immune response IgM
Secondary immune response IgG and is seen in 5-6 days.
Vaccinations provide protection against certain microorganisms due to the level of protection provided by IgG
An example of how antibodies protect the host from bacterial toxins tetanus is a bacterial toxin that has been inactivated, retains it anitgenicity, antibodies bind to the toxin & neutralizing it.
Created by: Wends1984