Busy. Please wait.

show password
Forgot Password?

Don't have an account?  Sign up 

Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.

Remove Ads
Don't know
remaining cards
To flip the current card, click it or press the Spacebar key.  To move the current card to one of the three colored boxes, click on the box.  You may also press the UP ARROW key to move the card to the "Know" box, the DOWN ARROW key to move the card to the "Don't know" box, or the RIGHT ARROW key to move the card to the Remaining box.  You may also click on the card displayed in any of the three boxes to bring that card back to the center.

Pass complete!

"Know" box contains:
Time elapsed:
restart all cards

Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

NURS 572 - 60

Ch. 60 Est/Progest non-contraceptive

General fx of estrogen/progesterone *sexual organs/menstruation *bone/prevent resorption, maint density, *cholesterol favorable effects
Estrogen given without progesterone can cause what adverse effects (first four) *endometrial hyperplasia *ovarian ca *breast ca *stimulates existing ca using estrogen receptors
Estrogen/progestin adverse effects (second four) *CV increase MI, DVT, CVA, VTE *GI A, N, V *GB cholelithiasis
Minor s/e of both est/progest jaundice, HA, depr, Na/H20 retent
Major non-contraceptive uses *HRT *female hypogonadism *acne *prostate ca
Routes of est/progest po, transdermal, vag, parenteral
SERMs definition selective estrogen receptor modulator
MOA of SERMs mixed action - agonist and antagonist
2 SERM drugs *tamoxifen *raloxifene
positive effects of both SERMs *tx breast ca *prevent osteoporosis *positive lipid effects
negative effects SERMs tamoxifen *hot flashes *endometrial ca *VTE
negative effect of SERM raloxifene *hot flashes *VTE *DOES NOT cause endometrial hyperplasia
General fx of endogenous progesterone *prepare/maintain uterine lining (secretory changes in leutal phase) *cervical secretions - inc. visc, dec amt *maint pg, inhibit uterine contractions *some estrogenic, adrogenic, anabolic effects
What might be given to prevent pre-term labor progestins to inhibit uterine contractions
first 4 ADRs of progestins *teratogenic fetus masculinization *menstrual irreg (BTB, amenorr) *cervical secretions dec amt, inc visc *if used with estrogen-->breast ca
second 3 ADRS of progestins *breast tenderness *depression *same misc as estrogen (and phto sens, wt gain, dec app)
Noncontraceptive tx uses of progestin *HRT *uterine dx (bleed, amenorr, endometriosis, endometrial ca) *PMS
how does progest effect uterine lining? it makes endometrium thinner to prevent ca
benefits of HRT *dec vasomotor menop effects *dec uroginital dysfx, atrophy *dec bone loss *dec colon cancer *maybe QOL
Is HRT established to provide a CV benefit? No, HRT has NOT been established to provide a CV benefit
Risks of HRT *CV events *if ET only, not EPT: ovarian, uterine ca *breast ca *cholecystitis, lithiasis
What do we give for HRT with in tact uterus pempro given for this uterine status
What do we give for HRT s/p hysterectomy? premarin given for this uterine status
Example of EPT drug pempro representative of this class
Example of ET drug premarin representative of this class
WHI, HERs study concenus *HRT NOT advised >4 yrs (long term) *IS advised < 4 years
WHI, HERs study short term uses *vasomotor menop sxs *osteoporosis *vulvar/vaginal menop atrophy
Created by: lorrelaws