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bi24 immune sys

grcc bi240 immune system aquired vs innate

Antigens foreign substances elicit a response by immune system
Antibodies proteins produced by the body in response to a specific antigen and capable of reacting against it
Innate immunity natural or built in
These are working all the time and are effective against many different kinds of microbes Innate immunity
External resistance factors Physical, chemical and cellular all inhibit bacteria growth
examples of innate immunity external factor: physical barriers skin, environmental conditions and flushing actions (eye lid blink, peristalsis and urination)
Examples of innate immunity external factor: chemical are activities carried out by molelcules salts, acids, lipids, enzymes
examples of innate immunity external factor: cellular are activities carried out by cells normal flora, phagocytes (macrophages, pMN leukocytes)
exampls of internal resistance factors: physical barriers such as connective tissue such as the blood brain barrier.
exampls of internal resistance factors: chemical activities carried out by molecules
exampls of internal resistance factors: chemical molecules enzymes, complement, membrane attack complex, interferon
Enzymes Lysozyme and other enzymes in blood and tissue fluids
Complement a naturally occuring, self regulating system consisting of about 30 proteins that is activated by polysaccharides or lipopolysacchiraides
Proteins that are activated by polysaccharides or lipopolysaccharides that are present on pathogens, including bacteria, fungi, etc.
membrane attack complex complement system activates this and forms channels onto bacteria. These channels disrupt the phospholipid bilayer of target cells, leading to cell lysis and death
exampls of internal resistance factors: interferons helps diminish viral replication
Interferon alpha & beta help diminish viral replicaton
interferon gamma is produced by type 1 T helper cells stimulated macrophage and also diminishes viral replciation
Acquired immunity acquired by infection or vaccination or by the transfer of antibody or lymphocytes from immune donor
Immune system is a coordinated effort between B and T lymphocytes
Immune system cells originate bone marrow, mature in bone marrow and thymus
Components of immune system Lymphatic, immune cells, chemical mediators.
Components of immune system: Lymphatic tissue lymph nodes, spleen, tonsils, and intestinal lymphoid tissue.
Components of immune system: Immune cells Originate in bone marrow and thymus (lymphocytes & macrophages) that id and remove foreign materials.
Components of immune system: chemical mediators Histamine and interleukins
Histamine and interleukins have a variety of functions involved in the immune reactions signal cell response, cause cell damage
Normal immune response happens in 2 phases clonal diversity and clonal selection
Generation of clonal diversity Lymphoid stem cells from bone marrow migrate to lymphoid organs where they proliferate
clonal diversity is generated by lymph stem cells from bone marrow then migrate to Lymphoid organs (thymus or bone marrow regions) where they proliferate and differentiate
The colonal diversity generates Immunocompetent T cells and B cells
Immunocompetent T cells from thymus
Immunocmpetetn B cells from bone marrow
Immunocompetent cells are formed and enter circulation & migrate to spleen and lymphnodes (which causes swollen lymph nodes)
Normal response: clonal selection is initiated by exposure to foreign antigen
result of clonal selection selective active cellular immunity or humoral immunity or both
humoral activates B-cells
clonal selection and proteinc on surface of cells antigens are proteins on surface of cell detect and elicit to destroy foreign material.
clonal selection elicits response with cell immunity is mediated by effector T cells, regulatory T cells and Memory T cells
Memory T cells can producce more antibody rapidly to a second challenge from the same antigen.
Humoral immunity is medated by soluble proteins (antibodies) produced in plasma cells and by memory B cells that produce more antibody rapidly to a second challenge with same antigen
What do monocytes lead to? macrophages = antigen presenting cells APC's)
Created by: Wends1984