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TL Non Cats
noncatecholamines
| Question | Answer |
|---|---|
| Name some general therapeutic effects that can be achieved with noncatecholamines. | local or systemic constriction of blood vessels; nasal and eye decongestion; dilation of bronchioles; smooth muscle relaxation |
| What is the main therapeutic effect of phenylephrine? | local or systemic constriction of blood vessels |
| Name some drugs used for bronchodilation. | albuterol, salmeterol, levalbuterol |
| Name a noncatecholamine used for nasal decongestion. | ephedrine |
| Name a noncatecholamine used for smooth-muscle (uterine) relaxation. | terbutaline (brethine for asthma) |
| How are noncatecholamines eliminated from the body? | in urine |
| Which type of andrenergic drugs can cross the blood brain barrier, catecholamine or noncatecholamine? | Noncatecholamines |
| How are noncatacholamines metabolized? | primarilary inactivated in the liver but also lungs, GI, and other tissues |
| Explain the difference in action between catecholamines and noncatecholamines. | noncatecholamines can be direct, indirect, or dual action whereas catecholamines are primarilary direct acting |
| Name a direct-acting noncatecholamine that stimulates alpha receptors. | phenylephrine |
| Name some noncatecholamines that stimulate beta 2 receptors selectively. | albuterol, isoetharine, metaproterenal, terbutaline |
| Name a dual acting noncatecholamine. | ephedrine |
| Which noncatecholamine would be useful to treat hypotension in cases of severe shock? | phenylephrine |
| Which noncatecholamine is useful to stop preterm labor? | terbutaline |
| What adverse interactions can take place between anesthetics (general), cyclopropane, and halogenated hydrocarbons if taken with noncatecholamines? | cardiac arrhythmias and hypotension –especially with mainly beta 2 active noncatecholamines like terbutaline |
| What drug type can cause severe hypertension and even death if combined with noncatecholamines? | Monoamine oxidase inhibitors |
| Why shouldn’t oxytocic drugs be combined with noncatecholamines? | Oxytocic drugs that cause uterine contractions may be inhibited by terbutaline. Oxytocic drugs taken with other noncatecholamines can cause hypertensive crises or stroke. |
| What adverse interaction could result from the combination of tricyclic antidepressants and noncatecholamines? | hypertension and arrhythmias |
| What kinds of drugs can slow excretion of noncatecholamines prolonging their duration of action? | Urine alkalizers like acetazolamide and sodium bicarbonate |
| What are the adverse reactions of noncatecholamines (HRAITDIISHHPADCCPPF)? | headache, restlessness, anxiety or euphoria, irritability, trembling, drowsiness or insomnia, incoherence, seizure, hyper/hypotension, palpitations, angina, dysrhythmias, cardiac arrest, cerebral hemorrhage, paresthesias, pallor/flushing |
Created by:
Perseverandovercome
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