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atyp typ antipsych

Aripiprazole (Abilify) Third generation
clozapine (Cloziril) Second generation
olanzapine (Zyprexa) Second generation
paliperidone (Invega) Second generation
quetiapine (Seroquil) Second generation
resperidone (Risperdal) Second generation
ziprasdone (Geodon) Second generation
chlorpromazine (Thorazine) First generation
thioridazine (Mellaril) First generation
loxapine (loxitane) First generation
molindone (Moban) First generation
perphemazine (trilaphon) First generation
trifluoperazine First generation
thiothixene (Navene) First generation
fluphenazine (Prolixin) First generation
haloperidol (Haldol) First generation
pimozide (Orap) First generation
chlorpromazine (Thorazine)potency Low potency
thioridazine (Mellaril)potency Low potency
loxapine (loxitane)potency Medium potency
molindone (Moban)potency Medium potency
perphemazine (trilaphon)potency Medium potency
trifluoperazine potency high potency
thiothixene (Navene)potency high potency
fluphenazine (Prolixin)potency high potency
haloperidol (Haldol)potency high potency
pimozide (Orap)potency high potency
Low potency = high sedation + high Ach + low EPS
High potency = low sedation + low Ach + high EPS
anticholorinergic effects blurred vision dry mouth decreased tearing dry nasal passages tachycardia constipation urinary hesitency
pisa syndrome leaning to one side elderly particularly susceptible
EPS dystonia, dyskinesia, akathisia, tardive dyskinesia
antiadrenergic effects hypotension postural hypotension tachycardia decreased cardiac output
cardiac effects longer qt interval fatal arrhytmias
endocrine effects amenorrhea, loss of labido, galactorrhea, inc risk osteoporosis impotence, gynecomastia, low sperm count, fiminazation
metabolic syndrome reduced metabolism glucose, resistance to insulin, DM2, obesity, inc lipid levels, hypertension, coagulation abnormalities
Neuroleptic Malignant Syndrome hypterpyrexia, muscular ridgity, tremors, alt conciousness, autonomic dysfux, HTN, tachycardia, tachypnea, diaphoresis, incontinence. Elev CPK, myglobinurea, elv WBC. Metabolic acidosis.
Treatment for NMS stop drug, administer bromocriptine mesylate (Parlodel), Dantrium, treat fever, maintain hydration, maintain vital fx
pseudoparkinsonism mask like, stiff/stoop posture, shuffling gait, drooling, tremor, pill rolling
dystonia contractions of tongue, face, neck, back, jaw
akethesia motor inner drive restlessness tapping foot, rocking foward/backward in chair, shifting weigh
tardive dyskensia protruding/rolling tongue, blowing, smaking, licking, spastic facial distortions.
Created by: 1161798020