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NSAIDs

QuestionAnswer
What is an NSAID? Non-steroidal anti-inflammatory drug.
NSAID: Action? Inhibit prostaglandin or leukotriene pathways of inflammation.
Prostaglandin pathway? Potentiates action of inflammatory substances (histamine, bradykinin) in production of edema and pain.
Leukotriene pathway? Also mediators of inflammation
NSAIDs: Indications? Headache, gout, diabetic neuropathy, hypertension, rheumatoid arthritis, osteoarthritis, pain relief (analgesia)
NSAIDs: Contraindications? Known drug allergy. Risk of bleeding.
NSAIDs: SE/AE? GI distress: heartburn, GI bleeding, mucosal lesions (aspirin)
NSAIDs: Toxicity? GI effects, tinnitus, CNS- dizziness, drowsiness; metabolic acidosis.
NSAIDs: Contraindications? Pregnancy, lactation, hepatic or renal disease, cardiovascular dysfunction, GI bleeding or peptic ulcers
NSAIDs: Obtain baseline on...? Skin lesions, temperature, orientation, vital signs, perfusion, CBC, liver/renal tests, stool guiac
Ibuprofen: What is it? Propionic acid agent
Ibuprofen: Max strength for nonprescription? 200 mg
Ibuprofen: Indications? Anti-inflammatory, analgesia, anti-pyretic. Used for: rheumatoid arthritis, osteoarthritis, dental pain, etc.
Ibuprofen: Trade names? Motrin, Advil
Ibuprofen: Contraindications? Pregnancy. Drug allergy
Ibuprofen: SE/AE? Dizziness, headache, somnolence (drowsiness), fatigue, rash, nausea, bleeding, constipation
Salicylates: Action? Inhibit prostaglandins. Anti-pyretic. Inhibits platelet aggregation (clotting)
Salicylates: Indications? Pain, fever, inflammatory conditions (rheumatoid arthritis, osteoarthritis). Prevention of stroke (CVA), heart attack (MI)
Salicylates: Contraindiations? Pregnancy, lactation, pediatric patients, those w/ bleeding tendencies.
What condition can salicylates cause in pediatric patients? Reye's syndrome: Potentially fatal disease, brain and liver effects, hypoglycemia. Rash, vomiting, and liver damage.
Salicylates: SE/AE? Nausea, vomiting, heartburn, epigastric discomfort, clotting, dizziness, tinnitis, diarrhea, tachypnea (rapid breathing), confusion
Aspirin: Indications? Prophylaxis of cardiovascular disease or stroke. (81 mg/day) Analgesic for headache, neuralgia (nerve pain), inflammation.
Aspirin: Children? Avoid in children with flu-like symptoms- may cause Reye's.
What is Toradol? Trade name: Keterolac. Used for analgesic effects. Requires prescription. Unique chemical structure. Only NSAID that can be given orally or injectable.
Created by: kangaloo