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Barry Patho I
Barry Anesthesia patho wk 2
| Question | Answer |
|---|---|
| What is the TBW % of a healthy M, F and Infant | Infant 70%, 60% Male, 50% female |
| Increased body fat affect TBW % by | decreasing TBW %, fat is hydrophobic |
| Describe the distribution of body water | ICF=40% (2/3) of body weight, ECF= 20% of body weight. |
| ECF is divided among what 4 compartments | Interstitial=15% f total body weight, Intravascular=5% of total body weight, lymphatic, and transcellular- (synovial peritoneal, ocular, cerebrospinal fluid) |
| Protiens are ____in plasma compared to the interstial fluid | higher |
| Average blood volume of a normal adult is | +- 5L |
| Pathology in these 2 systems have the greatest impact on the ability to maintain proper fluid balance | cardiac, renal |
| Increased fluid volume and decreased osmolality of ECF does what to the hypothalamus | inhibits the osmoreceptors in the hypothalamic thirst center |
| Decrease fluid volume and increase osmolality of ECF does what | stimulates osmoreceptors in the hypothalamic thirst center (creates sensation of thirst), also decreased saliva secretion |
| Describe Excitable cells | Have the ability to respond to electrical stimulation |
| Membrane potentials are influenced by | conc. of electrolytes in the ECF and ICF |
| Principle of osmotic neutrality | sum of cations and anions should be zero in the ICF and ECF |
| What are the body’s Cations | Sodium, Potassium,Calcium, Magnesium |
| What are the body’s Anions | Bicarbinate, Chloride, Phosphate, Protiens, others anions.. |
| What is the dominate cation ion in the ECF | Na+ ECF=[142], ICF [10] |
| What are the dominate anions in the ECF | bicarb EFC=[24], ICF [12], Chloride ECF=[104], ICF [4] |
| What are the dominate intracellular cations | potassium ICF=[156], ECF [5], Mg++ ICF[26], ECF [2] |
| What are the dominate intracellular anions | Phosphate ICF= [40-95], ECF=[2]; Protiens ICF [54], ECF [16] |
| Resting membrane potential | -70 to -85 milivolts, no change in charges, inside is neg, outside is pos. |
| Action potential | stimulus that exceeds threshold causes rapid change in resting membrane potential, due to influx of Na+ ions. Causes the inside of the cell to move to a charge of zero (depolarization) |
| Repolarization | return of the negative polarity to reach the resting membrane potential |
| Passive transport | does not use ATP, Moves in favor of the gradient, high-to-low |
| 4 types of passive transport | Diffusion (movement of solute), Facilitated diffusion |
| Active transport | requires ATP, moves against conc. gradient (low-to-high) |
| 2 types of Active transport | active (requires a carrier), and bulk transport |
| Descriptors of Bulk transport | exocytosis (movement of particles out of cell, i.e. secretion), endocytosis (moving particle into a cell), phagocytosis (solids), pinocytosis (liquids) |
Created by:
dupy6
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