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Barry Patho I

Barry Anesthesia patho wk 2

What is the TBW % of a healthy M, F and Infant Infant 70%, 60% Male, 50% female
Increased body fat affect TBW % by decreasing TBW %, fat is hydrophobic
Describe the distribution of body water ICF=40% (2/3) of body weight, ECF= 20% of body weight.
ECF is divided among what 4 compartments Interstitial=15% f total body weight, Intravascular=5% of total body weight, lymphatic, and transcellular- (synovial peritoneal, ocular, cerebrospinal fluid)
Protiens are ____in plasma compared to the interstial fluid higher
Average blood volume of a normal adult is +- 5L
Pathology in these 2 systems have the greatest impact on the ability to maintain proper fluid balance cardiac, renal
Increased fluid volume and decreased osmolality of ECF does what to the hypothalamus inhibits the osmoreceptors in the hypothalamic thirst center
Decrease fluid volume and increase osmolality of ECF does what stimulates osmoreceptors in the hypothalamic thirst center (creates sensation of thirst), also decreased saliva secretion
Describe Excitable cells Have the ability to respond to electrical stimulation
Membrane potentials are influenced by conc. of electrolytes in the ECF and ICF
Principle of osmotic neutrality sum of cations and anions should be zero in the ICF and ECF
What are the body’s Cations Sodium, Potassium,Calcium, Magnesium
What are the body’s Anions Bicarbinate, Chloride, Phosphate, Protiens, others anions..
What is the dominate cation ion in the ECF Na+ ECF=[142], ICF [10]
What are the dominate anions in the ECF bicarb EFC=[24], ICF [12], Chloride ECF=[104], ICF [4]
What are the dominate intracellular cations potassium ICF=[156], ECF [5], Mg++ ICF[26], ECF [2]
What are the dominate intracellular anions Phosphate ICF= [40-95], ECF=[2]; Protiens ICF [54], ECF [16]
Resting membrane potential -70 to -85 milivolts, no change in charges, inside is neg, outside is pos.
Action potential stimulus that exceeds threshold causes rapid change in resting membrane potential, due to influx of Na+ ions. Causes the inside of the cell to move to a charge of zero (depolarization)
Repolarization return of the negative polarity to reach the resting membrane potential
Passive transport does not use ATP, Moves in favor of the gradient, high-to-low
4 types of passive transport Diffusion (movement of solute), Facilitated diffusion
Active transport requires ATP, moves against conc. gradient (low-to-high)
2 types of Active transport active (requires a carrier), and bulk transport
Descriptors of Bulk transport exocytosis (movement of particles out of cell, i.e. secretion), endocytosis (moving particle into a cell), phagocytosis (solids), pinocytosis (liquids)
Created by: dupy6