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CMB-Chapter 14
CMB - Chapter 14 - Basic Pharmacology
Question | Answer |
---|---|
Pharmacology is the | study of the medications including their composition, indications, adverse effects, and how they act in the body |
Pharmacodynamics is the | study of what drugs do to the body. |
Pharmacokinetics is the | study of what the body does to drugs. |
ADME | absorption, distribution, metabolism, and excretion |
When a drug stimulates or increases the effect, the drug is called an | agonist |
When a drug inhibits or decreases the effect, the drug is called an | antagonist |
The therapeutic window concept is | the idea that medications have an optimal range where they work in |
The therapeutic index is | a measure of how safe medications are |
Therapeutic Index (TI) values are deternmined by taking | lethal dose of a given drug divided by the effective dose |
Absorption is | the method the body uses to take medication into the bloodstream |
Bioavailability is a | measure of how much of the drug actually gets into the blood to be distributed in the body |
Disintegration is | the process of breaking down into smaller parts as demonstrated by crushing a tablet |
Dissolution is | the ability of solid to dissolve to a liquid form |
? tend to work the fastest, followed by ?, and finally ? & ? | solutions, suspensions, tablets & capsules |
CD | controlled dose |
CR | controlled release |
ER | extended release |
IR | immediate release |
LA | long acting |
SR | sustanied release |
XL | extended release |
XR | extended release |
Distribution is | how the body moves the medication from the bloodstream to tissues or organs to exert its effect. |
Solubility is | the ability of a substance to dissolve in another substance. |
fat soluble medications tend to be eliminated by the | liver |
water soluble molecules tend to be eliminated by the | kidneys |
The volume of distribution (Vd) | gives an idea of where medications go in the body |
pH stands for | "power of hydrogen" |
Weak acids and weak bases are considered | "salts" of substances |
Generic names ending in "ine" are | bases |
Metabolism is | the body's attempt to make medication more polar so the medication can be easily eliminated. |
Excretion is | how the body eliminates a medication |
In ?, a constant amount of drug is eliminated over time | zero order kinetics |
almost all medications are eliminated by which type of kinetics | first order kinetics |
The half-life of a drug is | the amount of time it takes for half of the original medication to be eliminated |
When two medications work together, the medications are | synergistic |
When two medications inhibit each other, the medications are | antagonistic |
drug-drug interactions | two drugs are mixed together to create another effect |
drug-food interactions | drugs are affected by consuming certain food or drink such as grapefruit juice |
drug-disease interactions | drug can be harmful due to a medical condition |
Pharmacokinetic interactions occur when | one drug affects the absorption, distribution, metabolism, or excretion of the other drug. |
Pharmacodynamic interactions occur when | one drug adds to or neutralizes the other drug's effect without affecting the pharmacokinetics of the other drug. |
? neutralizes warfarin and is the antidote for warfarin overdose | Vitamin K |
Toxicology is | the study of poisons and how they affect the body |
antidote for APAP, Tylenol overdose is | Acetylcysteine (Acetadote, Mucomyst) |
antidote for Alcohol (ethanol) or fomepizole | Methanol or ethylene glycol |
antidote for Anticholinergics is | Physostigmine (Antilirium) |
antidote for Benzodiazepines is | Flumazenil |
beta-blocker antidote | Glucagon |
Black widow spider bite antidote | Antivenin (Latrodectus mactans) |
Calcium channel blockers antidote | Ca |
Carbon monoxide antidote | oxygen |
Cyanide antidote | Amyl nitrate |
Digoxin antidote | Digoxin Immune Fab |
Epinephrine antidote | Phentolamine |
Heparin or enoxaparin antidote | Protamine |
Narcotics/Opiates antidote | Naloxone |
Nerve gas poisoning antidote | Pralidoxime (2-PAM, Protopam) |
Tricyclic antidepressant antidote | Sodium bicarbonate |
Theophylline or caffeine antidote | Esmolol |
The ? regulates (or controls) muscles that we have voluntary control over, such as biceps and triceps | somatic nervous system (SoNS) |
The ANS is composed of the | sympathetic nervous system (SNS) and the parasympathetic nervous system (PSNS) |
The SNS is | the "fight or flight" system; heart, lungs |
The PSNS is | the "rest and digest" system; stomach, |
The SNS is also referred to as the ? because the SNS nerves branch out from this part of the spinal cord | thoracolumbar system |
When alpha receptors are stimulated, the result is | the excitation/stimulation/constriction of the organ or tissue |
When beta receptors are stimulated, the result is | the relaxation/inhibition/dilation of the organ or tissue |
The PSNS is also referred to as the ? because the PSNS nerves branch out at this part of the spinal cord | craniosacral system |
? receptors are found primarily in the arteries | Alpha |
? receptors are found primarily in the heart and the lungs | Beta |
Beta-l receptors are found in the | heart |
Beta-2 receptors are found in the | lungs |
Muscarinic receptors (e.g., M2 and M3) are found throughout the | digestive tract, in the eye, the heart, the lungs, and the bladder. |
When muscarinic receptors are stimulated, muscles | contract |
? receptors are found on voluntary skeletal muscle such as biceps, deltoids, etc. | Somatic |
myosis | nearsightedness |
mydriasis | farsightedness |
Stimulation of muscarinic receptors results in a | decrease in heart rate. |
When the muscarinic receptors are over-stimulated, ? occurs because the contents are being moved too quickly through the digestive system | diarrhea |
When the muscarinic receptors are over-inhibited, ? occurs because the contents are not being moved quickly enough | constipation |
The digestive system also has ? receptors | alpha-2 |
When ? receptors in the urinary bladder are stimulated, the urinary bladder relaxes and urine stays in the bladder | beta-2 |
When ? receptors are stimulated, the urinary bladder contracts and urine is pushes out of the bladder into the urethra to be eliminated. | muscarinic |
Giving two medications within the same drug class or very similar drugs that do practically the exact same thing is | an additive drug-drug interaction (duplication) |
When alpha receptors in the arteries are stimulated, the arteries | constrict and narrow the pathway blood enters to increase pressure. |
The three main muscles in the eye are the | radial, circular, and ciliary muscles. |
The radial and circular muscles allow us to have | near and far vision. |
The ciliary muscle allows us to | be able to see clearly during near and far vision. |
? is the automatic adjustment of the lens in the eye to improve the clarity during near and far vision | Accommodation |
in the heart, ? stimulate the heart to contract which increases contractility and blood pressure | beta cells |
beta-1 stimulants such as dobutamine should be used in | cardiac shock |
Stimulation of muscarinic receptors results in a | decrease in heart rate. |
When alpha receptors are stimulated, arteries | constrict, which increases blood pressure |
? is commonly used for anaphylactic shock | Epinephrine |
The lungs have ? receptors which are found on the bronchioles | beta-2 |
When beta receptors in the bronchioles are stimulated, bronchioles | relax (or dilate) to increase the amount of air entering the lungs. |
When beta receptors are inhibited, the bronchioles | constrict, and wheezing may occur. |
The digestive system also has ? receptors | alpha-2 |
Alpha-2 receptors are | sensory receptors that give the body an idea how much acetylcholine is being released. |
Tachyphylaxis is | a condition where the effectiveness of the medication diminishes over time. |
Alpha-1 antagonists, such as doxazosin (Cardura), are commonly used for | benign prostate hyperplasia (BPH) |