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NURS 572A-13b

Chapter 13 PNS receptors

QuestionAnswer
activation of Nn receptors promotes - 3 1-psymp gang transmission 2-symp gang transmission 3-symp adrenal medulla transmission
activation of Nm receptor promotes sk muscle contraction
Muscarinic activation causes - 7 1-increased glandular secretions 2-sm mus contraction in bronchi/GI 3-decreased HR 4-miosis - iris sphincter contraction 5-near-focus ciliary muscle contraction 6-bvessel dilation 7-urinary voiding
Location of Alpha-1 receptors - 5 1- eyes 2- blood vessels (skin, viscera, mucous mem arterioles . . .veins) 3- male sex organs 4- prostatic capsule 5 - bladder (trigone & sphincter)
Location of Ocular Alpha-1 receptors radial muscle of iris
Activation of Ocular Alpha-1 leads to mydriasis - dilation of pupil bwo contraction of radial muscle
Activation of Bvessel Alpha-1 leads to vasoconsriction
Location of bvessel Alpha-1 receptors *veins *arterioles of skin, viscera & mucous mems
Activation of male sex organ Alpha-1 leads to ejaculation
Activation of bladder/prostatic Alpha-1 leads to contraction (trigone & sphincter)
Location of Alpha-2 receptors on nerve terminals, not on organs
Alpha-2 receptors referred to as presynaptic or prejunctional
Function of Alpha-2 receptors to regulate ntran release
Example of Alpha-2 receptor function PNS NE released from presyn, binds Alpha-2 on same presyn to suppress further NE release
Are drug effects significant PNS Alpha-2 activation No. Alpha-2 PNS drugs minimal significance
Are drug effects significant CNS Alpha-2 activation yes Alpha-2 CNS receptors important
Location of Beta-1 receptors -2 1-heart 2-kidney
Dopamine role in PNS vasodilates kidney vessels --> increased urine excretion/flow
Muscarinic receptors target voluntary or involuntary effector organs? Involuntary organs effected by this receptor
Adrenergic is to sympathetic nervous systems as muscarinic is to . . . parasympathetic nervous system
Muscarinic is to parasympathetic nervous system as adrenergic is to . . . sympathetic nervous system
Which adrenergic receptor is of greatest therapeutic significance? Cardiac Beta-1
Three actions of activating cardiac beta-1 1-increase heart rate 2-increase force of contractions 3-increase velocity of AV node conduction
Primary action of activating renal beta-1 causes release of renin
Action of activating pulmonary beta-2 bronchial dilation
Action of uterine beta-2 activation relaxes uterine smooth muscle
Action of heart/lung/skeletal muscle vessels by beta-2 activation vasodilation
Action of beta-2 activation in liver/skeletal muscle glycogenolysis, enhance muscle contraction
General action of activating Nn receptors-2 1-stimulate sym/psym postgang 2-Epi release from adrenal medulla
General action of activating Nm receptor sk muscle contraction
2 Effects of activating ocular muscarinic receptor 1-miosis 2-near vision focus
Effect of cardiac muscarinic activation decrease HR
Effect of lung muscarinic activation bronchial constriction
Effect of bladder muscarinic activation urine excretion (contract detrusor, relax trigone/sphincter)
4 effects of GI muscarinic activation 1-salivation 2-gastric secretions 3-increased intestinal tone/motility 4-defecation
Unusual fact about sweat glands nerves that supply ACh (to activate muscarinic receptors) belong to sympathetic, NOT parasympathetic
effect of sex organ muscarinic activation erection
effect of muscarinic activation of blood vessels vasodilation
Epinepherine activates these 4 receptors alpha-1, alpha-2 beta-1, beta-2
norepinephrine activates these 3 reeptors alpha-1, alpha-2 beta-1
dopamine activates these receptors alpha-1, beta-1, dopamine
which receptor type is more specific? adrenergic or cholinergic? adrenergic is selective. ACh can activate all 3 subtypes of cholineric receptors. Not every adrenergic transmitter activates all 5 subtypes of adrenergic receptors
Beta-2 receptors ONLY activated by epinephrine, to prepare body for flight/fight
Created by: lorrelaws
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