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Apoptosis
| Question | Answer |
|---|---|
| Define apoptosis | Programmed cell death |
| When does apoptosis occur? | When BCL2 is blocked |
| Define necrosis | When bacteria infect a cell and cause it to burst. Not the same as apoptosis |
| What is the function of a capsase? | It cleaves things during apoptosis |
| From what are capsases created? | inactive procaspases |
| Extrinsic Pathway: 1. killer _____ binds to trimeric _____ receptor and triggers binding of _______ adaptors and procaspases | lymphocyte, Fas,FADD |
| Extrinsic Pathway: 2. Union of FADD Fas and lymphocyte creates _______ | DISC |
| Extrinsic Pathway: 3. Procaspases become _______ which activate ____________ and apoptosis occurs | caspases, executioners |
| Intrinsic Pathway: 1. Mitochondria is signaled by ___ and _____ stress to release _______ into the cytosol | p53, hypoxia, cytochrome C |
| Intrinsic Pathway: 2. BCL2 is inhibited by ___ and ____ so Bax Bak can form cytochrome C channel in outer mitochondrial matrix | Noxa, Puma |
| Intrinsic Pathway: 3. Cytochrome C binds to _____ to alter shape and initiate apoptosome formation | Apaf1 |
| Intrinsic Pathway: 4. ______ domains of Apf1 stick together and bind to ____ domain on top of _________ | CARD, CARD, procaspase |
| Name three ways in which apoptosis is blocked | 1. BCl2 protein over produced 2. inactivation of pro-apoptotic BH3-only Bcl2 protein 3. inactivation of anti-IAPs |