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Apoptosis

QuestionAnswer
Define apoptosis Programmed cell death
When does apoptosis occur? When BCL2 is blocked
Define necrosis When bacteria infect a cell and cause it to burst. Not the same as apoptosis
What is the function of a capsase? It cleaves things during apoptosis
From what are capsases created? inactive procaspases
Extrinsic Pathway: 1. killer _____ binds to trimeric _____ receptor and triggers binding of _______ adaptors and procaspases lymphocyte, Fas,FADD
Extrinsic Pathway: 2. Union of FADD Fas and lymphocyte creates _______ DISC
Extrinsic Pathway: 3. Procaspases become _______ which activate ____________ and apoptosis occurs caspases, executioners
Intrinsic Pathway: 1. Mitochondria is signaled by ___ and _____ stress to release _______ into the cytosol p53, hypoxia, cytochrome C
Intrinsic Pathway: 2. BCL2 is inhibited by ___ and ____ so Bax Bak can form cytochrome C channel in outer mitochondrial matrix Noxa, Puma
Intrinsic Pathway: 3. Cytochrome C binds to _____ to alter shape and initiate apoptosome formation Apaf1
Intrinsic Pathway: 4. ______ domains of Apf1 stick together and bind to ____ domain on top of _________ CARD, CARD, procaspase
Name three ways in which apoptosis is blocked 1. BCl2 protein over produced 2. inactivation of pro-apoptotic BH3-only Bcl2 protein 3. inactivation of anti-IAPs
Created by: neeck
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