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Microbio Lecture 20

Viral Diseases I

QuestionAnswer
causes of common cold Rhinovirus*, Adenovirus, Reovirus, Coronavirus
describe main common cold agent +ssRNA virus with 100+ serotypes. targets nose for cooler temperature
common cold symptoms headache, dry throat, runny nose, fever, chills
common cold transmittance aerosols, fomites, hand to hand contact
cures and preventions of common cold zinc/zycam binds ICAM-1 nose receptors, acid-tissue, washing hands, vitamin C increases interferon production, hot soup
respiratory synctial disease virus paramyxoviridae family. helical, -ssRNA, enveloped
RSV pathogenicity as virus replicates, it moves to other cells and causes cells to fuse to form synctia which malfunction, die, and slough off (alters cell structure in lungs)
symptoms of rsv fever, runny nose, coughing, inflammation of bronchioles, wheezing, dyspnea, asymptomatic in adults
RSV transmission fomites, hands, aerosols
RSV diagnosis immunoassay
RSV treatment supportive! 1) breathing tube 2) fever reducers 3) IV 4) IgGs bind to RSV
influenza causative agent Orthomyxoviridae family. 8 -ssRNA helices
agent structure influenza 8 helices, 8 capsids, 1 matrix protein, 1 envelope, spikes contain hemaglutinin and neuraminidase
which disease has 2 glycoproteins and what are their functions influenza. hemaglutinin attaches to ciliated epithelial cells, neuraminidase assists with entry/exit, snips sialic acid from carbs on cell membrane
types of influenza A, B, C. a is the worst, natural host is birds, subtypes based on which combo of N and H
antigenic drift and antigenic shift antigenic drift occurs because RNA polymerase is error prone. antigenic shift is the mixing of H and N by two different virus subtypes
pathogenicity of influenza H binds to epithelial cell receptor N assists entry virus enters by endocytosis replicates. spreads in 6 hrs. cells slough off (mucosal elevator is destroyed).
influenza symptoms body aches, chills, fever, nasal congestion, tight chest, myalgia. usually self-limiting
complications of influenza caused by Staphylococcus aureas, haemophilus influenzae, and streptococcus pneumonia
complications of influenza 1. Guillain -Barre Syndrome: paralysis, nerve damage, coma = temporary damage 2. Reye's Syndrom: kids with flu + aspirin
treatment and prevention of influenza Symmetrel (Amantadine): prevents uncoating Oseltamivir (Tamiflu): neuraminidase inhibitor Vaccine
Herpesviridae family linear DNA virus, have enveloped, polyhedral capsules, enter by membrane fusion
HHV1 oral herpes, gingivostomatitis (cold sore on throat), ocular herpes (herpes keratitis), whitlow
HHV2 genital herpes, neonatal herpes (--> herpes encephalitis
HHV1/2 transmission cracks/cuts in membranes
HHV1/2 pathogenicity virions bind receptors on epithelial cells. infect and multiply dead cells = blisters/sores virus retreats into nerves reactivated by sunburn, physical/emotional stress, fever
treatment of HHV 1/2 acyclovir and thymidine kinase enzyme
HHV3 causes chicken pox/varicella and herpes zoster/shingles
HHV3 is double strand DNA, icosahedral enveloped virion
HHV3 transmission respiratory droplets of skin contact of pox
HHV3 treatment: vaccine
HHV3 pathogenicity infects resp. tract, skin, or eyes. travels thru blood to nerves and skin. multiplies in cutaneous tissue and forms pox
HHV3 treatment acyclovir
what is shingles migrates down nerves and replicates trunk
warts agent human papilloma virus. non-envelope DNA virus
types of warts each virus targets different tissue. plantar warts = feet. genital warts = condylomata
HPV associated with cervical cancer
treatment of warts they disappear or by freezing
transmission of warts fomites
Created by: syeonie
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