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Microbio Lecture 21

Viral Diseases II: Visceral and Neurotropic

QuestionAnswer
what makes up the vicera? small/large intestines. liver, spleen, blood
viscerotropic diseases transmission bodily fluids from infected individuals, contaminated food/drink, arthropods
yellow fever +ssRNA, icosahedral, enveloped virion of flaviviridae family
what kind of virus is yellow fever arbovirus
yellow fever transmission mosquitos (Aedes aegypti) and infected monkeys
yellow fever pathogenicity blood --> lymph nodes --> organs where hemorrhaging occurs
yellow fever symptoms black vomit, bilirubin, jaundice
yellow fever prevention mosquito population control and attenuated virus vaccine
mononucleosis agent epstein barr virus: enveloped, icosahedral, DNA herpesvirus
mono transmission oropharyngeal secretions
pathogenicity of mono virus infects B-lymphocytes (mononuclear WBC) which proliferate and cause symptoms. cytotoxic t cells kill lymphocytes
infected lymphocytes are aka downey cells
diagnose mono 1) monospot slide test: heterophile agglutination test 2) measure IgM and IgG
symptoms of mono lymph nodes enlarged, spleen, fever, fatigue, sore throat - spleen may rupture
treatment of mono self-limiting but asymptomatic carrier
what is EBV associated with? 1) Burkitt's lymphoma 2) nasopharyngeal carcinoma 3) chronic fatigue syndrome/MS
hepatitis A virus +ssRNA, icosahedral NO ENVELOPE, picornaviridae family aka heparnavirus
Hepatitis A transmission 1) fecal-oral 2) food 3) water contaminated feces
HAV is resistant to chemical or physical agents
HAV symptoms 2-4 wks: anorexia, nausea, fever, abdominal pain, vomit then later jaudice
HAV diagnosis 1) check liver functions 2) check HAV abs 3) can be asymptomatic carriers
HAV treatment no fried foods or alcohol
prevention of HAV remove source of outbreaks. vaccinate. self healing.
hepatitis B virus hepadna virus, enveloped, DNA (ss + ds)
hepatitis B virus transmission shed into saliva/semen/vaginal secretions and transmitted through breaks in skin/mucous membranes
HBV associated with hepatocarcinoma
HBV symptoms 4-6wks, fatigue, anorexia, taste changes, dark urine, wierd poop color, and jaundice
types of HBV 1) dane particles (complete virion) 2) filamentous particles and 3) spherical particles (have surface antigens but cannot replicate)
HBV treatment none. prevent with vaccine and safe sex
ebola virus causes ebola hemorrhagic fever
EBV is ssRNA filvirus, natural host unknown
EBV symptoms massive internal bleeding, blood squirts, organs turn to liquid
EBV pathogenicity 2 glycoproteins: one enters endothelial cells of blood, replicates, and weakens vessels causing leakage 2) attaches to neutrophils and limits phagocytosis
neurotropic viral diseases viruses cross blood-brain barrier easier than bacteria and fungi due to small size
west nile agent flaviviridae family, + ssRNA icosahedral envelope
west nile transmission mosquitos: birds = natural hosts. blood transfusion, organ transplants, breast-feeding, pregnancy. no kissing/touching
WNV symptoms fever, headache, nausea, vomiting, swollen lymph glands, skin rash, encephalitis or meningitis
WNV prevention no standing water or put mosquito-eating fish
Rabies virus helical, enveloped -ssRNA Rhabdoviridae
Created by: syeonie
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