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Lipid Study Guide
| Question | Answer |
|---|---|
| Describe the Structure of a fatty acid | Composed of methyl end (CH3) and terminal carboxylic acid group which is hydrophilic. length can be from 4-24 carbons and includes SFA, MFA, PUFA, Cis or Trans fatty acids |
| List 2 essential fatty acids. why are they essential? | Linoleic & alpha linolenic. humans lack the enzymes needed to double bond at the apha 12 and alpha 15 positions. fatty acid chains can be elongated by enzymatic addition of two carbon atoms at the carboxylic acid end of the chain. |
| What composition of dietary fat do triglycerides comprise? | 95% of dietary fat |
| Structure of a triglyceride | trihydroxy alcohol, glycerol, 3 fatty acids attached by ester bonds |
| Structure of a sterol | 4 ring core structure |
| Role of a sterol | essential component of the cell membrane and a precursor for important compounds such as bile acids, sex hormones, vitamin D |
| Structure of phospholipid | contains phosphate and one or more fatty acid residues |
| Role of phospholipid | component of cell membranes (phospholipid bilayer); emulsification of fat. |
| Structure of lipoprotein | made of lipids and proteins. Phospholipids are a single layer around lipoprotein. small amount of cholesterylester and triacylglycerols in the surface layer and a little free cholesterol in the core |
| Different composition of various lipoproteins | chylomicrons contain little protein but high triglycerides and have a low density. -VLDL-LDL-HDL: high protein, low triglycerides. As the density of concentration of protein goes up and triglycerides go down, density increases and size decreases. |
| Function of apoproteins | protein component of lipoprotein. allows lipoprotein to be recognized by certain cells. Stimulates enzymatic reactions. |
| Function of LDL | LDL reacts with LDL receptor, Apo B100 on cells. LDL particles are bound then internalized into cells. Components are degraded by lysosomal enzymes in the cell. |
| Describe LDL receptor functions | LDL receptor Apo B100 on cells interacts with LDL. LDL particles are bound then internalized into cell. particle componeonts are degraded by lysosomal enzymes in the cell. |
| primary function of HDL | Reverse cholesterol transport - remove chol from cell and return it to the liver for excretion in bile. |
| Name the enzyme that hydrolyses a triglyceride at C1 and C3 to form a monoglyceride during lipolysis | Hormone Sensitive Lipase |
| What happens to glycerol during lypolysis | glycerol is transported to the liver and can be converted to dihydroxyacetone phosphate which can produce energy. |
| Describe the process of mitochondrial transfer of acyl CoA | Carnitine acyl transferase 1 transfers FA into the inner membrane space of the mitochondria and CAT2 allows it into the matrix of the mitochondria |
| What molecule is used to transfer long chain fatty acids into the mitochondria | Carnitine |
| Name the three ketone bodies | Acetoacetate, beta hydroxybutyrate, acetone |
| When do ketone bodies become present in large amounts in the body? | High levels occur in accelerated FA oxidation combined with Low CHO intake (ex: diabetics not in control of blood sugar, starvation, low CHO diet) |
| What is the starting molecule in ketone body synthesis? | Acetyl CoA |
| What is the starting molecule in cholesterol synthesis? | Acetyl CoA |
| enzyme targeted by drug therapy to decrease serum cholesterol. | HMG CoA reductase |
| Two key components of fatty acid sythase system | Acyl carrier protein (ACP) and condensing enzyme (CE) |
| List the 3 categories of eicosanoids | Prostaglandins, Thromoxanes, leukotrienes |
| Describe the process of atherosclerosis as the body's response to injury? how do dietary chol and fatty acids impact this process? | Platelet derived growth factor (PDGF) attracts monocytes to injured area, monocytes respond, slide under injury to subendothelial space along with LDL. |