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Path lab block 3

facts not in lecture

risk factors for benign fibroadenoma of the breast (versus malignancy) younger pt (<30), mass is long-standing, mobile and appears to have smooth, well defined borders. AA women get multiple fibroadenomas
Fibroadenoma of the breast collagenous stroma and distorted, slit-like, elongated ducts
risk factors for benign hamartoma of the lung non-smoker, male, asymptomatic, 45-60 yo, nodule is well demarcated, relatively small and has central calcifications Chromosomal aberrations of 12q and 6p have also been found in chondroid or cartilaginous hamartomas
histology of benign hamartoma of the lung benign appearing mature cartilage and trabecular bone. The calcified bone corresponds to the calcifications seen in the lesion on imaging. The tissues appear well-differentiated
malignant tumor of the lung histology tumor consists of large epithelial cells in sheets. Some of the cells have open- appearing nuclei, others are dark and irregular with a high nuclear:cytoplasmic ratio. Occasional keratin formation is seen. Intercellular bridges may be present
risk fators/signs for malignancy of the lung male, smoking, weight loss, cough or hemoptysis are signs
invasive breast adenocarcinoma appearance/histology non-calcified, ill defined solid mass with irregular and infiltrative margins non-calcified, ill defined solid mass with irregular and infiltrative margins
does a female pt having a sister who got breast cancer at age 70 put her at higher risk for breast cancer likely not as significant since her sister was diagnosed at an older age (70 years)
appearance of liposarcoma MRI shows large, lobulated mass with prominent thin and thick septa. grossly tumor appears well-circumscribed, close resemblance to fatty tissue-pale yellow and homogeneous in appearance compared to the adjacent normal fat MALIGNANT
histology of liposarcoma fat cells w/ areas of fibrous tissue. Enlarged hyperchromatic cells w/ irregular nuclei scattered among normal adipocytic nuclei. Rare cells are immature adipocytes w/ small cytoplasmic vacuoles which sharply indent/scallop the nucleus (lipoblast)
Dedifferentiated liposarcoma - facts and histology well-differentiated liposarcoma component adjacent to a pleomorphic high-grade sarcoma component - dedifferentiated liposarcoma - hypercellularity, spindle cells, pleomorphic, high mitotic rate - 15-30% chance of metastases, more aggressive local growth
poorly differentiated breast carcinoma pathology sheets of pleomorphic cells with hyperchromasia, prominent nucleoli, coarse chromatin, and an increased nuclear:cytoplasmic ratio. The tumor has a prominent associated lymphocytic infiltrate. Duct formation is not readily identified
what tests would you order for a poorly differentiated breast carcinoma? Estrogen and progesterone receptor expression, HER2/neu amplification (RTK - protooncogene), or BRCA1/2 mutations (TSG)
Neuroendocrine tumor/carcinoid tumor diagnosis An immunostain for CD56, synatophysin, chromogranin immunostain. Neuroendocrine tumor cells: round, monotonous, "salt and pepper" chromatin, scant cytoplasm, eosinophilic neuroendocrine granules (and maybe rosettes), well defined nests
goodpasture syndrome Type II hypersensitivity - anti BM Ab attacks glomerular BM and alveolar BM
Created by: erupe