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BIO 2117 CHAP 15
AQUIRED IMMUNITY: ESSENTIAL CONCEPTS
| Question | Answer |
|---|---|
| FORMED FROM STEM CELLS FORMED IN THE BONE MARROW | B-CELLS & T-CELLS |
| FORIEGN MATERIAL THAT B & T CELLS ARE DESIGN TO INTERACT WITH | ANTIGEN |
| HUMORAL (IN THE BLOOD) IMMUNITY (PRODUCTION OF ANTIBODIES) | B-CELLS |
| INVOLVED IN CELL MEDIATED IMMUNITY | T-CELLS |
| ANTIGENS TOO SMALL TO BE DISCOVERED BY IMMUNE SYSTEM /ATTACHES TO PROTEINS - CARRIER MOLECULE | HAPTENS |
| ANTIGEN ACTVATES B-CELL, ________ _______FURTHER STIMULATE B-CELL IS CO-STIMULATION | HELPER T-CELL |
| DIVIDES INTO PLASMA CELLS(MAJORITY) & MEMORY B-CELLS(IN CASE YOU RUN INTO ANTIGEN AGAIN)(MINORITY) | ACTIVATED B-CELL |
| PRODUCE ANTIBODIES, RELEASE IN BLOOD STREAM OR LYMPH | PLASMA CELLS |
| MONOMER, DIMER, PENTAMER | (3)CLASSES OF ANTIBODIES |
| *MAKES UP 80% CIRCULATING IN BLOOD PLASMA *CAPABLE OF CROSSING PLACENTA * | IgG |
| SECRETORY (SALIVA, MUCOUS, BREAST MILK) | IgA (DIMER) |
| 1ST GROUP FORMED @ INTITIAL RESPONSE | IgM (PENTAMER) |
| SURFACE OF B-CELLS (RECEPTOR FOR ANTIGEN TO BIND) | IgD |
| SURFACE OF MAST CELLS & BASOPHILS (ALLERGIES) | IgE |
| COMPLEMENT FIXATION/ OPSONIZATION/ NEUTRALIZATION(COVER RECEPTORS W ANTIBODIES)/ AGGLUTINATION (CLUMPING) | ANTIBODY FUNCTIONS |
| REQUIRES THAT ANTIGENS ARE PRESENTED | T-CELLS |
| B-CELLS ,MACROPHAGES, & DENDRITIC CELLS | ANTIGEN PRESENTING CELLS |
| (MEMORY CELLS) HELPER T-CELLS & CYTOTOXIC T-CELLS | T-CELLS ACTIVATED & DIVIDE WHEN ANTIGEN IS PRESENTED INTO 2 CLASSES |
| ON SURFACES OF ANTIGEN PRESENTING CELLS (ANTIGEN HELD AND PRESENTED) | MHC II MARKERS |
| MARKERS ON T-CELLS | CD4 HELPER T-CELLS CD8 KILLER T-CELLS |
| DESTROY OTHER CELLS(VIRAL INFECTED, PLAYS ROLE IN REJECTING TRANSPLANTED TISSUE, TARGET CANCER CELLS) | CYTOTOXIC T-CELLS |
| *CO-STIMULATE B-CELLS/ OTHER T-CELLS *ENHANCE INFLAMMATION (RELEASING INFLAM CHEM) *RELEASE CHEM TO STIMULATE LEUKOCYTE FORMATION | HELPER T-CELLS |
| LATENT PERIOD (NO PRODUCTION OF ANTIGEN) IgM THEN IgG (NOT INTENSE, SHORT LIVED) PRODUCE MEMORY CELLS | PRIMARY RESPONSE |
| NO LATENT PERIOD, INTENSITY IS GREATER & LASTS LONGER, IgM & IgG SIMULTANEOUSLY DEVELOP | SECONDARY RESPONSE |
| NATURAL ACTIVE(OWN IMMUNE RESPONSE), NATURAL PASSIVE(BREAST FEEDING) ARTIFICIAL ACTIVE(VACCINES), ARTIFICIAL PASSIVE(I V DRIP) | 4 TYPES ACQUIRED IMMUNITY ACTIVE VS PASSIVE, NATURAL VS ARTIFICIAL |
| INACTIVATED VIRUS (DEAD) ATTENUATED VIRUS (TAKEN AWAY VIRULENCE, SOMETIMES MUTATE BACK) | WHOLE CELL VACCINES |
| TOXOID (INACTIVATED BACTERIAL TOXINS) SUGARS FROM CAPSULE (MENINGITIS), SPIKES OF VIRUS/ NO PATHOGEN PRESENT | SUB-UNIT VACCINE (ACELLULAR) (EXPENSIVE) |
| SURFACE ANTIGEN(SPIKES) PUT GENE INTO YEAST & GROW /NO PATHOGEN PRESENT | RECOMBINANT VACCINE |
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