Save
Upgrade to remove ads
Busy. Please wait.
Log in with Clever
or
show password
Forgot Password?
Don't have an account?  Sign up 
Sign up using Clever
or
Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account. Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't Know
Remaining cards (0)
Know
0:00
edit
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

antimicrobials

Stack #72373

antimicrobialmode of actionspectrum of activityrandom factstype of anit microb
Aminoglycosides (Bactericidal)-streptomycin, kanamycin, gentamicin, tobramycin, amikacin, netilmicin and neomycin freeze 30S initiation complex so no further initiation can coccur , slow down protien syntheseis and induce misreading of mrna ONLY good foaerobic bact. Many gram neg some gram pos Reisstanc common, can be toxic to kidney, ototoxicity, synergise with B-lactiam DON"T GIVE PATIENTS WITH DIURETICS (may cause deafness) bind to 30 S ribosomal subunit
Tetracyclines -tetracycline, minocycline and doxycycline reversibly bids to 30S ribosome and inhibit biding of aminoacyl tRna to Asite on 70 S ribosome broad spectrum usefull against intracellualr bacteria Resistance = common Adverse effects = destruction of normal intestial flora Bind to 30S ribosomal subunit
spectinomycin reversibly interferes with mrna interaction with 30S ribosome. like aminogrlycosides by does not cause misreading of mRNA Treatment of penicillin resistant neisseria rare resitstance in Neisseria goorrhea Bind to 30S ribosomal subunit
Chloramphenicol, lincomycin, clindamycin bind to 50S ribosime and inhibit peptidyl transferase activity C= broad ranbe, L and Cl = restricted range Resistance = common, Adverse = chlormaphenicol is toxic and used to treat bacterial meningitis 50 S ribosomal subunit
Macrolides (Erythromycin) inhibit translocation gram positive bact. Mycoplasma Legionella resistance commone, very big moleule 50 S ribosomal subunit
Fusidic acid binds to elongation factor and inhibits the release of EF-G from EF-GDP complex gram pos cocci (blank) interfere with Elongation factors
Rifampin,rifamycin rifampicin (bactericidal) bind to DNA-dependent RNA polymerase and inhibit initiation of RNA synthesis wide spectrum but most commonly used intthe treatment of tuberculosis resistanc = common Combination thearpy - rifampin is usual used in combination therapy Inhibit RNA synthesis and function
quinolones ( Nalidixic acid, ciprofloxacin, oxolinic acid) bind to the A subunit of DNA gyrase (topoisomerase) and prevent supercoiling of DNA, thereby inhibiting DNA synthesis Gram positive coci and UTI Resistance= common for nalidixic acid; developing for ciprofloxacin DNA synthesis and function
sulfonamides, sulfones para-aminobenzoic acid and competatively inhibit formation of dyhydropetric acid. They competatively inhibit the incorpration of PABA into folic acid, thereby preventing the stynthesis of folic acid broad range actvity against grampositive and gram neg bacteria and used primarily in UTI and in Nocardia infections resistence = common Combo therapy = suled with trimethoprim , it blockes 2 distinct steps in folic acid metabolism and prevents the emergence of resistant strains TMP/SMX combo = UTI infection TMP/SMX pneumocytis carnii Inhibit folic acid synthesis
trimethoprim binds reversibly to and inhibits dihyrofolate recuctase, an enzyme that reduces dihydrofolic acid to tetrahydroflic acid, decreasing folic acid synthesis broad range activity against gram positive and gram negative bacteria used primarly in UTI infections and in Nocardia infections Resistance = common Combo therapy = Trimethoprim is used in combo with trimethoprim Inhibit folic acid synthesis
Para-aminocalicylic acid (PSA similar to sulfonamides specific for Mycobacterium tuberculosis inhibits mycolic acid antimycobacterial agents
Dapsone similar to sulfonamides used in treatment of leprosy (blank) antimycobacterial agents
Isoniazid (INH) ingibid synthesis of myclic acids used in the treatment for tuberculosis resistance has developed antimycobacterial agents
Beta lactams ( Penicillin), Cyclosporins (Cephalosporin) Vancomycin Inhibit cell wall synthesis (cephalosporin given to patients with sensitivity or allergic reactions to peniciliin Gram neg are less sensitive to inhibitors of cell wall synthesis (blank) Cell wall synthesis
Bacitracin inhibit transpor of cell wasll components by carriers Binds to the undecaprenyl pyrophosphate lipid carrier that transpor the peptidoglycan monomers across the bacterial membrane streptococcus pyogenes gram neg less sensitive to inhibitors of cell wall synthesis too toxic for human use Cell wall synthesis
Polymyxin B Binds membrane and disrupts integrity Gram neg less sensitive to inhibitors of cell wall synthesis Resistance= B-lactam resistance, B-lactamase inhibitors Cell wall synthesis
Created by: melissape
Popular Biology sets

 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!
"Know" box contains:
Time elapsed:
Retries:
restart all cards