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Neurochemistry Fall

PBD Neurochemistry Test 2

QuestionAnswer
Rate limiting step for synthesis of glutamate? glutaminase
2 routes of glutamine reuptake 1. Metabolized by glutamine synthase in glia 2. Glutamine autoreceptor (Calcium dependent)
Glutamate receptor subtypes (4) 1. Kainate 2. NMDA 3. AMPA 4. Metabotropic
What is long-term potentiation? a long-lasting enhancement in signal transmission between two neurons that results from stimulating them synchronously?
What is excitotoxicity? Characterized by: Excessive glutamate release which leads to NMDA/kainate stimulation which increases intracellular Calcium. This ultimately leads to cell swelling/death
What is epilepsy? excess excitation and depolarization in foci
Blocking glutamate receptors can help treat what? epilepsy
Why is the NMDA receptor different than the other glutamate receptors? can increase intracellular Calcium ion levels
1. Kainate (excitatory or inhibitory?) 2. Type of Receptor? 3. Molecular effects? (intracellular) 1. Excitatory 2. Ionophore 3.Increase Na+ Decrease K+
1. NMDA (excitatory or inhibitory?) 2. Type of Receptor? 3. Molecular effects? (intracellular) 1. Excitatory 2. Ionophore 3. Increase Ca++ and Na+ Decrease K+
1. AMPA (excitatory or inhibitory?) 2. Type of Receptor? 3. Molecular effects? (intracellular) 1. Excitatory 2. Ionophore 3. Increase Na+ Decrease K+
1. Metabotropic Glutamate Receptor (excitatory or inhibitory?) 2. Type of Receptor? 3. Molecular effects? (Intracellular) 1. Excitatory or Inhibitory?????????? 2. GPCR 3. Decrease cAMP Increase IP3
Major pathway in the brain (Glutamate) Cortex to striatum
How is glutamate synthesized? Glutamine is synthesized to glutamate by glutaminase
Created by: 1096890584
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