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hEMETOLOGY EXAM 3
ANEMIA'S
| Question | Answer |
|---|---|
| what % of transferrian is bound to Fe? | 30% |
| how is intravscular distingusihed from extravascular hemolysis? | urine hemsiderin |
| what other tests are utilized in the detection of hemolytic anemia? | bilirubin haptoglobin urine hemosiderin |
| what is the reticulocyte value for anemia? | hemolytic anemia retic |
| how can hgb A and Hgb S be confirmed? | hgb electrophoresis using acid agar |
| what is the intrinsic factor and what disease is deficient in IF? | It is needed to absorb B12 Pernicious Anemia (PA) |
| what is the peupose of the Schilling test? | detects malabsorption of B12 found in PA |
| how can IDA and anemia of chronic disease be distinguished? | Ferritin decreased TIBC increased |
| what is the breakdown product of hgb? | urobilinogen |
| what is a product of heme synthesis? | one of the porphyrins (uroporphyrin or coproporhyrin) |
| which thalassemia is more serious? | alpha thalassemia major |
| since hematocrit is calculated on the coulter instrument, will increased WBC affect the hct? | yes |
| what power is used to see BM megs? | low power |
| what do Karryohexis and asynchrony indicate? | defective DNA synthesis |
| at what point do normal RBC normally lyse in an osmotic fragility? | approx 0.5% NaCl |
| what anemia type is found in liver disease? | macrocytes |
| what chemistry tests are increased in hemolytic anemia? | bilirubin and LD |
| which anemia has the most polychromasia? | hemolytic |
| ringer sideroblasts on an iron stain indicate what? | sideroblasts anemia |
| are hypersegmented neutrophils reported? | yes |
| What anemia do you see hypersegmented neutrophils? | meglobalstic anemia |
| will cold agglutination and increased WBC affect the hct? | yes cold agglutination increases the MCV, which is used to get the hct? |
| will lipemia affect the hct? | no |
| in aplastic anemia what is the BM cell:fat ratio? | 10;90 |
| if the wrong type of blood is transfused, what type of hemolysis is found? | intravascular hemolysis |
| what is the fetal hgb content for sickle cell trait? | normal Hgb F (1:30%) |
| what is the M:E ratio for erythroid hyperplasia? | 1:1 |
| how is the M:E ratio calculated? | # of myeloid cells/#of erythroid cells |
| in normal BM, what % of WBC are the more mature cells? | 50% of neutrophils are myleocytes, metmyleocytes, bands, segs |
| what is the advantage of using automated instruments? | increased precision |
| what is the normal M:E ratio? | 3:1 |
| what is the M:E ratio in anemia? | 1:1 |
| what are the indices for a hgb of 8.0gm/dL? | cannot determine |
| when is basophilic stippling observed? | thalassemia and lead poisoning |
| the retic value is____ after treatment for IDA, folate, B12 | increased |
| retic value is _____ in spherocytosis | increased |
| retic values are _____ in aplastic anemia | normal or decreased |
| retic values are ______ in untreated folate deficiency | normal or decreased |
| composition of Howell-J body | DNA |
| composition of retic | RNA |
| composition of heinz body | precipitated hgb |
| composition of pappenheimer | Fe |
| composition of N-RBC | DNA |
| composition of C crystals | precipitated hgb |
| what anemia is associated howell-jolly inclusions | megloblastic anemia, hemolytic anemia |
| what anemia is associated basophilic stippling inclusions | lead poisoning, thalassemia |
| what anemia is associated with pappenheimer inclusions | hemolytic anemia, megloblastic anemia, sideroblastic anemia |
| what anmeia is aasocatied with cabot ring inclusions | megloblastic anemia and myelodysplastic syndrome |
| what anemia is heinz body associated with | G6PD |
| what is the morphology of hereditary spherocyosis | spherocytes, polychromasia, n-RBC (possible) |
| what is the morphology of hemolytic anemia in newborn | increased n-RBC, macrocytic/normochromic |
| what is the morphology of immune hemolytic aneima | spherocytes, schistocytes, polychromasia, n-RBC |
| what is the morphology of aplastic aneima | pancytopenia, normocytic, normochromic |
| what is the morphology of megaloblastic aneima (triad abnornalities) | oval macrocytes, hypersegmented, and H-J bodies |
| what is the morphology of the non megaloblastic aneima | round macrocytes, leukocytes, and platelet counts usually normal |
| Beta- thalassemia major morphology | increased n-RBC, microcytes, hypochromasia, target cells, basophilic stippling, many tear drops, many schistocytes, polychromasia |
| thalassemia minor morphology | microcytosis, slight hypochromasia, target cells, basophilic stippling |
| IDA morphology | hypochromic and microcytic |
| hgb C crystal morphology | target cells, spherocytes, microcytes, polychromasia |
| hgb sickle cell morphology | sickle cells, target, n-RBC, schistocytes, H_ body, baso stippling, polychromasia, |
Created by:
bekah1125
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