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Define toxidrome. A toxic syndrome made up of a constellation of signs and symptoms that consistently result from particular toxins.
Name some common toxidromes. Cholinergic. Anticholinergic. Narcotic/opioid. Sedative/hypnotic. Sympathomimetics. Hallicinogenics.
What does a cholinergic toxidrome lead to? Elevated levels of acetylcholine.
What are common cholinergics? Nicotine. Mushrooms.
What are common anticholinesterases. Organophosphates. Carbamate insecticides. Nerve gas (sarin). Urethanes.
What are common organophosphates? Nerve gasses. Insecticides. Herbicides.
What are the symptoms of cholinergenic overdose. DUMBELS= Diaphoresis, diarrhoea, decreased blood pressure. Urination. Miosis. Bronchorrhea, bronchospasm, bradicardia. Emesis, excitation of skeletal muscle. Lacrimation(tears). Salivation, seizures.
What is the management for cholinergic toxidromes? Atropine and supporting ABC's.
What are anticholinergic drugs? Drugs that generally interfere with the binding of acetylcholine to muscarinic receptors.
What is the result of anticholinergic drugs affecting acetylcholine's binding? The parasympathetic nervous system is inhibited or blocked.
What are examples of anticholinergic drugs? Atropine. Antihistamines. Antipsychotics. Antiparkinsons. TCA's.
What are the symptoms of anticholinergic toxidromes? Altered LOC: agitation, hallicinations. Mydriasis (pupil dilation) and blurred vision. Hot, dry, flushed skin - hyperthermia. Dry mucus membranes. Tachycardias'palpations,arryhythmias. GI: Urinary retention, decreased bowel sounds.
What are the management for anicholinergic toxidromes? Support ABC. Monitor ECG. IV.
Created by: boermedic