Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Met.biochem L7
Better Antibiotics
| Question | Answer |
|---|---|
| What do antibiotics do? | -affect protein synthesis -interact W cell membrane -useful for ones that target bacteria wall |
| what antibiotic targets bacteria wall? | -penicillin |
| Effects of penicillin | -bacteria osmotically unstable -lyse |
| Park nucleotides | -UDP W NAMA(short peptide) & NAG |
| UTP | -carrier of glycopeptides -form rigid wall of bacteria |
| Bands of polysaccharides | -B1-4linkages -btwn NAMA & NAG in 1 direction |
| Peptidoglycan | -rigid wall formed to prevent swelling/shrinking |
| penicillin on bacteria | -transpeptidase inhibitor -blocks formation of X-links |
| B-lactam bond | -structural analogue of D-ala bond -in penicillin |
| Co-existence of B-lactams & B-lactamases... | -indicates evolution of microorganisms which seek to secure own ecological niches against competitors |
| Vancomycin | -prevents hydrolsis & X-linking -attaches to D-ala -favoured->resistant strains are rare |
| Resistant transfer (Via sex-pilus) | -bacteria have plasmid with resistance -transferred readily |
| Nucleotide analogues | -deficient nucleic acid -inhibit polymerases -effect R/DNA prod. |
| intercalating compounds | -stabilise helix -harder to separate for DNA replication |
| Erythromycin | -translocation -tetracycline -Blocks site A |
| Chloramphenicol | -peptidyl transferase -forms bonds between aa at A&P site |
| Mitochondrial ribosomes | -antibiotics effect these -anaemia first sign |
Created by:
meglet
Popular Science sets