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Hypersensitivity Reactions

Anaphylaxis Type I
Allergic rhinitis (hay fever) Type I
Asthma Type I
Eczema Type I
IgE mediated: free Ag cross-links IgE on presensitized mast cells and basophils --> trigger release of vasoactive amines Type I
Ab mediated: IgM, IgG bind fixed Ag on cell--> lysis by complement or phagocytosis Type II
Immune complex mediated: Ag-Ab complex activates complement --> attract neutrophils --> neutrophils release lysosomal enzymes Type III
Delayed (T-cell) mediated: sensitized T lymphocytes encounter Ag --> release lymphokines --> macrophage activation Type IV
Contact dermatitis Type IV
Allergic rhinitis & anaphylaxis Type I
Hemolytic anemia Type II
Idiopathic thrombocytopenic purpura Type II
Erythroblastosis fetalis Type II
Rheumatic fever Type II
Goodpasture's syndrome Type II
Bullous pemphigoid Type II
Graves' disease Type II
Myasthenia gravis Type II
SLE Type III (immune complex)
Rheumatoid arthritis Type III (immune complex)
Polyarteritis nodosum Type III
Post-strep glomerulonephritis Type III
Serum sickness Type III (immune complex)
Arthus reaction Type III
Hypersensitivity pneumonitis Type III (immune complex)
Type I diabetes mellitus Type IV
Multiple sclerosis Type IV
Guillain-Barre syndrome Type IV
Hashimoto thyroiditis Type IV
Graft vs host disease Type IV
PPD (TB test) Type IV
Contact dermatitis Type IV
Type II (Ab-mediated) IgM, IgG bind to Ag on "enemy" cell-->lysis or phagocytosis
Type III (immune complex) Ag-Ab complexes activate complement which attract PMNs who release dangerous substances
Type IV (delayed) Sensitized T cells encounter Ag and release lymphokines to activate macrophages
Type III (serum sickness) Fever, urticaria, arthralgias, proteinuria, lymphadenopathy 5-10 days after Ag exposure
Created by: srebeiro