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bio 122 3
chap 16 the lymphatic system
| Question | Answer |
|---|---|
| when substances are exchanged with the blood and tissue fluid does more fluid leave the blood capillaries or return to them | leave |
| what is the excess fluid that leaves the blood capillaries called | lymph |
| what is the name for the fluid that is in the tissue | interstitial fluid |
| lymphatic pathways: where do they begin | in closed ended capillaries |
| lymphatic pathways: list the order that the lymph travels from lymph capillary to subclavian | capillaires; vessels; nodes; trunk; collecting duct; subclavian vein; now is called plasma! |
| lymphatic pathways: when the lymph empties into the subclavian vein its name changes to what | blood plamsa |
| lymphatic pathways: def of lymph capillaries; similar to what | close ended simple squamous epithelium; blood capillaires |
| lymphatic pathways: lymphatic vessel- def, do they have valves? why | large vessel structured like a vein; yes, there is no BP there so this controls the flows of lymph |
| lymphatic pathways: lymphatic trunk- def; they converge into what; they are named after what | these are vessels that drain into large areas of the body; collecting ducts; parts of the body they are located |
| are tissue fluid and lymph the same?; why? | yes; they are the same stuff just found in different places |
| tissue fluid: where does it come from | blood plasma which leaves the cappillaries as water and dissolved substances |
| tissue fluid: what substance always remains in the capillaries | large plasma proteins (globulins, albumins, fibronogens) |
| tissue fluid: what is important in osmotic pressure needed to move materials back into blood capillary | plasma proteins |
| tissue fluid: some small proteins are able to leave the blood capillary and enter the interstitial fluid creating its own _____ pressure; this pressure forces the tissue fluid where | osmotic pressure; lymph capillaries |
| tissue fluid: how is the epithelium of the lymph capillary unique | the cells overlap eachother and act like valves so fluid can be forces inside but once in the capillary it cannot leave |
| function of lymph | the lymph brings a lot of bacteria and other foreign material into the capillary |
| movement of lymph: lymph is controlled by what; the movement is similar to what other structure's movement | muscular activity (breathing muscles, contraction of larger vessels), veins |
| def of edema | acculilation of fluid in interstial space |
| lymph nodes: contain alot of what 2 things; structure; name the places they are located | macrophages and lymphocytes (they fight bacteria); hilum (like a kidney) where BV and nerves enter and leave, lymph vessels enter anywhere and leave at hiluml cervical; axillary, inguinal, pelvic, abdominal, thoracic |
| lymph nodes:what is the function | formation of lymphocytes and macrophages |
| what are the 2 lymph organs | thymus and spleen |
| thymus: it is largest when; smallest us: when; as the thymus ages the tissue is replaced by what | in children; adults; adipose orconnective tissue |
| thymus: it is divided into what; what type of WBC are located here | lobules; lymphocytes; |
| thymus: the lymphocytes develop into what; what is the name for the hormone that the thymus secretes; this hormone stimulates ____ to mature where | T cell lymphocytes; thymosin; stimulates the T-cells to mature outsite the thymus gland |
| what is the largest lymph organ | the spleen |
| spleen: what lobules are similar to what?; what are the lobules filled with what | the sinuses of the lymph nodes; blood instead of lymph |
| spleen: what are the 2 types of pulp | white and red |
| spleen: where does a fetus produce RBC? why | in the red pulp; a fetus does not have bone (hyaline cartilage) do that means no red bone marrow |
| body defense against infection: def of immunity | the body's defense mechanisms against pathogenic agents |
| nonspecific immunity : name the types | species resistance, mechanical barriers, chemical barriers, inflammation, phagocytosis, fever |
| nonspecific immunity : what is the 1st line of defense | species resistance, mechanical barriers |
| nonspecific immunity : what is the 2nd line of defense | chemical barriers, inflammation, phagocytosis, fever |
| nonspecific immunity :def of chemical barriers; ex | enzymes are present in various body fluids that can destroy pathogens; pepsin in stomach, tears, interferons, densins |
| chemical barriers: def of interferons | a group of hormone like peptides produced by cells in response to the presence of viruses or certain tumors that interferes with the reproduction of a virus |
| chemical barriers: interferons stimulate what | phagocytosis and enhance the activity of cells that resist infections and the growth of tumors |
| chemical barriers: def of inflammation | tissue response to infection and injury helps prevent spread of pathogens |
| chemical barriers: def of fever | a nonspecific defense that begins as a viral or bacterial infection stimulates lymphocytes to proliferate, producing cells that secrete a substance called interleukin; this increase temp |
| def of specific immunity | the resistance to specific pathogens or to their toxins or metabolic by product, it involves lymphocytes and monocytes |
| antigens: early in life cells learn to identify self, so any that comes into the body is identified as what | nonself; |
| antigens: the T and B lymphocytes have what on their surface that do that | receptors that recognize the foreigners and initiate antibodies to destroy them |
| antigens: haptens- def; how are they able to initiate an immune response | molecules to small to initiate an immune response; they bind to a larger molecules that then will initiate the immune response |
| T lymphocytes aka | thymus derived lymphocytes |
| antibodies: def | antibodies are soluable globular proteins called immunoglobulins that account for the gamma globulins of plasma proteins- that light chains and heavy chains |
| antibodies: the light and heavy chains are made of what | amino acids |
| types of immunoglobulins: aka; name the five types; they are determined by what ; the type of immunoglobulin dermines what | antibodies; IgG, IgA, IgM, IgD, IgE; the amino acid sequence on its free end; how the antigen will be destroyed |
| allergic reaction: occurs when an abnormal amount of _____ are produced in response to what | antibodies; antigen |
| allergic reaction: the antibodies attach to what; and the secrete what; this causes what classic symptoms of an allergic reaction | the membrane of the mast cells and basophils; histamines, prostaglandins, leukotrienes; swollen tissue, contraction of bronchial tube; contraction of intestinal muscles; increased mucous production |
| allergic reaction: what stops the reaction before it becomes too severe | the suppressor T cells |
| tissue rejection reaction: the transplanted tissue is interpreted by the body as what; the body develops what reaction against the tissue; what reduces this reaction | a foreign antigen; immune reaction; close donor matches and immunosuppressive drugs |
| def of autoimmunity | when the immune system fails to distinguish self cells from nonself cells, the body's own immune system attacks and damages its tissues and organs |
| the epicardium has what other name | visceral pericardium |
| what layer of the heart secretes the serous fluid | the epicardium |
| lymphatic vessels transport excess fluid away from _______ and return it to __________ | the interstitial space; blood stream |
| def of patheogen | disease causing agents |
| the lymphatic capillaries parallel what other network | the blood capillaries |
| walls of lymphatic capillaries similar to what wall | blood capillaries |
| lacteal: where located; what is their function | the lining of the small intestines; absorbs digested fats then transports fats to venous circulation |
| lymphatic vessels similar to what | veins |
| lymphatic vessels: how many layers; do they have valves | 3; yes |
| lymphatic vessels: lead to specialized _____ | lymph nodes |
| lymphatic trunks: lumbar trunk- drains lymph from where | lower limbs, lower abdominal wall, pelvic organs |
| lymphatic trunks: intestinal trunk- drains lymph from where | abdominal viscera |
| lymphatic trunks: intercostal and bronchomediastinal trunk- drains lymph from where | portions of the thorax, |
| lymphatic trunks: subclavian trunk- drains lymph from where | upper limb |
| lymphatic trunks: jugular trunk- drains lymph from where | neck and head |
| collecting ducts: what are the 2 | thoracic and right lymphatic |
| collecting ducts: what one is largest | the thoracic |
| collecting ducts: thoracic duct- where is it located; empties where; drains whtat | abdomin and passes up through the diaphram; left subclavian; intestinal lumbar, intercostal trunks, left subclavian and jugular |
| collecting ducts: R lymphatic duct- where is it located; empties where; drains what | originates in R thorax at union of right jugular; R subclavian; from upper right side of the body |
| after leaving the 2 collecting ducts lymph enters ____ and becomes ______` | venous system; part of the plasma prior to blood returning to the R atrium |
| lymph formation depends on what other formation | tissue fluid formation |
| lymph formation: filtration from the plasma exceeds what; this increases the ______ pressure; this favors the tissue fluid to mvoe to where | reabsorption; tissue fluid hydrostatic pressure; favors tissue fluid movement to the lymphatic capillaries |
| lymph formation prevent what | excess tissue fluid accumulation or edema |
| lymph returns all small proteins that left the blood plasma to where | the blood stream |
| lymph capillaries: what is special about their epithelial cells | they overlap but are not attached to eachother |
| lymph capillaries: the overlap of the epithelial cells create a flap like valves in the capillary wall, these are pushed in when; but they close when | when the pressure is greater on the outside of the capillary ; close when the pressure is greater on the inside |
| what largely influnces the movement of lymph through the lymphatic vessels | muscular activity |
| does lymph have a low or high hydrostatic pressure | low |
| when does lymph flow peak ; why | during exercise ; due to the skeletal muscles and pressure changes associated with breathing |
| lymph nodes: aka; they contain a large number of what 2 things | lymph glands; lymphocytes and macrophages |
| structure of a lymph node: BV and nerves join it through where; lymph vessels join it where; where does BV lymph vessels and nerves leave | the hilum; the convex surface; the hilum |
| structure of a lymph node: what enclose eahc lymph node | a capsule of connective tissue with numerous fibers |
| structure of a lymph node: def lymph nodules ; these contain what | the node is partially subdived into these; masses of dividing lymphocytes and macrophages |
| structure of a lymph node: what is the structural unit of the lymph node | the lymph nodule |
| structure of a lymph node: why is a tonsil unique | it is composed partially of encapsulated lymph nodules |
| def of pyers patches; located where | aggregates of lymph nodules; mucous lining of the distal portion of the small intestines |
| lymph nodes: cervical- location | mandible, ears, deep with in the neck, along paths of larger vessels |
| lymph nodes: axillary- location | underarm region, drain mammary glands, thorax, and upper wall of abdomen |
| lymph nodes: supratrochlear- location | located superficially on the medial side of the elbow |
| lymph nodes: inguinal- location | receive lymph from the lower limbs, external genitals, lowe abdominal wall |
| lymph nodes: pelvic- location | they follow the iliac BV, receive lymph from the lymphatic vessels of the pelvic viscera |
| lymph nodes: abdominal- location | abdominal cavity, receive lymph from the abdominal viscera |
| lymph nodes: thoracic- location | present in the mediastinum, trachea and bonchi; receive lymph from he thoracic viscera |
| lymph nodes: what are the 2 primary functions | filtering potential harmful particles before returning the the bloodstream and monitoring body fluids immune surveilance |
| lymph nodes: what are the sites for lymphocyte production | red bone marrow and the lymph nodes |
| thymus: def | soft bilobed structure enclosed in a connective tissue capsule |
| spleen: location; why does it resemble a large lymph node | upper left portion of the abdominal cavity; it is enclosesed in a connective tissue capsule and is divided in lobules |
| spleen: with the chambers it is filled with what instead of lymph | blood |
| spleen: the red pulp contains numerous what | Red blood cells with many lymphocytes and macrophages |
| what do macrophages do | the engulf ad destroy foreign particles |
| the spleen filters blood just as much as what filters lymph | the lymph node |
| defense against infection: def of nonspecific defense | mechanisms that are quite general and protect against many types of pathogens, they function is the same way regardless of the invader that enters |
| defense against infection: def of specific defense ; aka | a more direct response carried out by a specialized lymphocyte that recognizes foreign molecules in body; immunity |
| defense against infection: nonspecific- species resistance- def; | a given kind of organism develops disease that are unique to it and it is resistant to diseases that affect other species b/c it is not right environment for disease |
| defense against infection: nonspecific- mechanical barriers: what are they; what do they do | skin mucous membrane; prevent the enterence of of some infectious agents |
| defense against infection: nonspecific- mechanical barriers: what happens as the skin sloughs off | it removes superficial bacteria with it |
| defense against infection: nonspecific- mechanical barriers: what does the fluid in the mucous membrane do | it washes away organisms before they become firmly attached |
| defense against infection: nonspecific- chemical barriers- def | enzymes in body fluid |
| defense against infection: nonspecific- chemical barrier- what does pepsin do | it has low pH due to presense of HCl the combined effect kills many pathogens |
| defense against infection: nonspecific- chemical barrier- what do the enzymes in tears do | this enzyme, lysozyme acts against certain bacteria on the eyes |
| defense against infection: nonspecific- natural killer cells- aka; def | NK cells; a small population of lymphocytes distinctly different from the lymphocytes that provide adaptive defense mechanisms |
| defense against infection: nonspecific- inflammation- what does it produce; what does the reddness result in; why do WBCs accululate at site; why does tissue fluid collect their; | localized rednnes, swelling, heat and pain; BV dilation that increases blood flow and volume with in the affected tissue; they help control pthogens; they contain fibrogens do form the meshwork |
| defense against infection: nonspecific- phagocytosis- what does it do; def of chemotaxis; | removes foreign particles from the lymph as it moves from the interstitial spaces to the blood stream; chemical released from injured tissue atract these cells |
| defense against infection: nonspecific- phagocytosis- what engulfs smaller particles; larger particeles | neutriphils; monocytes |
| defense against infection: nonspecific- fever- what does it do; what substance causes it | elevated body temp inhibits microbial growth and inreases phagocytic activity; interleukin-1 it raises the thermoregulatory set point in hypothalamus |
| defense against infection: nonspecific- fever- high body temp causes liver and spleen to stop producing what; this does what to bacteria | iron; iron is needed for bacteria as temp rises and with out it they die |
| defense against infection: specific- immunity- an immune response is based on what ; what are the particles called that initiate the immune response | the ability to distinguish self from nonself; antigens |
| defense against infection: specific- antigens- nonself is called what; what antigens are more likely to initiate an immune response | foreign antigens; large and complex with few repeating parts |
| defense against infection: specific- during fetal development percursers to lymphocytes are released from red bone marrow into what 2 places | thymus and stay in red bone marrow |
| defense against infection: specific- the percursers to lymphcytes that go the thymus specialize into what | T lymphocytes/ t cells |
| defense against infection: specific- the precursers to lymphcytes that remain in the red bone marrow develop into what | b lymphcytes |
| defense against infection: specific- what type of lymphocyte is 70-80% | the T lymphocytes |
| defense against infection: specific- how do T lymphocytes respond to an antigen; how do B lymphocytes respond to an antigen | attach to foreign antigen- bearing cells are have cell to cell contact; they divide and diffiantiate and produce antibodies |
| defense against infection: specific- the of cellular immune response | when the T cells interact and attach to the antigen directly |
| defense against infection: specific- where is the origin of undifferentiated cells | the red bone marrow |
| defense against infection: specific- def of helper t cell ; what happens once it is activated | it is activated whne its antigen receptor combines with displayed foreign antigen; the helper t cell stimulates the B cell to produce antibodies that are specific for that antigen |
| defense against infection: specific- what cell is the prime target for HIV | the CD4 |
| defense against infection: specific- tcells- what does the cytotoxic cell do | it recognizes nonself antigens that concerous cells or virally infected cells display .. . . more for cancer |
| defense against infection: specific- t cells- what does the memory t cell do | these cells remember that foreign antigen and they know how to respond the next time, an differiante into cytotoxic |
| defense against infection: specific- Bcells- when do they become activated | when it encounters an antigen whose molecular shape fits the shape of a B cells antigen receptor, then it divides |
| defense against infection: specific- antibody molecule- what does it look like; how many chains ; why are the heavy chains heavy | a y; four chains 2 heavy and 2 light; they constist of twice the amount of amino acids as the light ones |
| defense against infection: specific- antibodies- how do they react in a direct attack | the combine with antigens and cause them to clump or form insoluble substances |
| defense against infection: specific- immunoglbins- IgG- where is it found | plasma and tissue fluid |
| defense against infection: specific- immunoglbins- IgA- where is it found | exocrine gland secretions |
| defense against infection: specific- immunoglbins- IgM- where is it found | plasma |
| defense against infection: specific- immunoglbins- IgD- where is it found | surface of most B lymphocutes |
| defense against infection: specific- immunoglbins- IgE- where is it found | exocrine gland secretions |
| immune response- def of primary | plasma cells release antibodies into the lymphafter the B ad T cells become activated from an antigen |
| immune response- def of secondary | the memory cells in future on second exposure |
| classifications of immunity: naturally aquired active immunity | develops after a primary immune response and is a response to exposure to a live pathogen and develops s/s |
| classifications of immunity: artificially aquired active immunity | a vaccine w/ one glycoprotein from pathogen surface is enough for foreign antigen to alert the immune system, no s/s |
| classifications of immunity: artificially aquired passive immunity | an injection of antibodies or antitoxins, the recipients cells do not produce the antibodies |
| classifications of immunity: naturally aquired passive immunity | immunity from mom 6 months to a year after birth (blood and breast milk, does not develop immune response |