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MCB305 Lecture 2
Cell Membranes
| Question | Answer |
|---|---|
| Phosphatidylcholine | most abundant/common, on both sides of membrane, most cells have |
| Phosphatidylethanolamine | sometimes more asymmetric in other cells |
| Phosphatidylserine | only on inner leaflet, negative charge, asymmetric, signal for apoptosis |
| Apoptosis | membrane flip inside out --> pserine is on outside of cell signalling other cells to destroy it |
| Phosphatidylinositol | rare, used in signal transduction |
| Sphingomyelin | found in lipid raft: strong concentrationof cholesterol, protein, and the lipid; promote signal transduction-not directly |
| Lipid rafts | thicker than rest of layer (sphingo=thicker); proteins tend to accumulate in these rafts; enhance signal transduction |
| Amphipathic | transmembrane proteins are amphipathic-polar (heads) and non polar (tails) regions |
| Movement of proteins | laterally, spin, can't flip flop (top/bottom switch) because of the charges/polarity |
| Symport | the transport of two moelcules in the same direction (coordinated uptake of glucose and Na+) |
| Uniport | transport of only a single molecule (facilitated diffusion of glucose) |
| Antiport | two molecules are transportedi n oppoiste directions (Na+-H+ antiporter regulates intracellular pH by removing excess H+ and preventing acidifcation of the cytoplasm) |
| Carrier proteins (pumps) | bind specific molecules to be transported undergoing conformational changes to allow for release on the opposite side of membrane; work via facilitated diffusion or active with input of ATP |