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MCB305 Lecture 2

Cell Membranes

QuestionAnswer
Phosphatidylcholine most abundant/common, on both sides of membrane, most cells have
Phosphatidylethanolamine sometimes more asymmetric in other cells
Phosphatidylserine only on inner leaflet, negative charge, asymmetric, signal for apoptosis
Apoptosis membrane flip inside out --> pserine is on outside of cell signalling other cells to destroy it
Phosphatidylinositol rare, used in signal transduction
Sphingomyelin found in lipid raft: strong concentrationof cholesterol, protein, and the lipid; promote signal transduction-not directly
Lipid rafts thicker than rest of layer (sphingo=thicker); proteins tend to accumulate in these rafts; enhance signal transduction
Amphipathic transmembrane proteins are amphipathic-polar (heads) and non polar (tails) regions
Movement of proteins laterally, spin, can't flip flop (top/bottom switch) because of the charges/polarity
Symport the transport of two moelcules in the same direction (coordinated uptake of glucose and Na+)
Uniport transport of only a single molecule (facilitated diffusion of glucose)
Antiport two molecules are transportedi n oppoiste directions (Na+-H+ antiporter regulates intracellular pH by removing excess H+ and preventing acidifcation of the cytoplasm)
Carrier proteins (pumps) bind specific molecules to be transported undergoing conformational changes to allow for release on the opposite side of membrane; work via facilitated diffusion or active with input of ATP
Created by: trangn
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