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Neuro core
| Question | Answer |
|---|---|
| SE phenobarb | sedation, hyperactivity |
| SE phenytoin | gingival hyperplasia, BM suppression |
| SE primidone | sedation, hyperactivity |
| SE ethosuximide | GI upset, HA |
| SE carbamazepine (tegretol) | low Na, low WBC, hepatitis |
| SE valproate (depakote) | low plts, hepatitis, pancreatitis |
| SE felbamate | aplastic anemia |
| SE gabapentin | sleepiness |
| SE lamotrigine (lamictal) | rash (incrsd w VPA) |
| SE topirimate (topamax) | cognitive slowing, renal stones |
| SE tiagibine | dizziness, somnolence |
| SE levtiracetam (keppra) | sleepiness, psych disturb in kids |
| SE oxcarbazepine (trileptal) | low Na |
| SE zonisamide (zonex) | renal stones |
| which sz meds can be given IV | phenobarb, phenytoin, valproate, levetiracetam |
| tx for tourette | psych dopa agonists like haloperidol, pimozide + clonidine |
| tx for tremor (3) | bb, primidone, topamax |
| which sz med esp good for tuberous sclerosis | tigabitran |
| SE tigabitran | VF loss |
| how bring out breath holding spell | for pallid (pain related), press on eye |
| when does stroke appear on CT | after 3 days |
| when does hemorrhage show up on MRI | after 3 days |
| how does hemorrhage appear on MRI | ID, BD, BB, DD (T1/T2 <3d, 3-7d, >7, chronic) |
| key components orbitofrontal | emotion, attn, impulse (assoc limbic) |
| key components medialfrontal | motivation (lesion gives akinetic mutism, apathetic state) |
| key components dorsolateral frontal | attn, working memory, sequencing (spelling WORLD backwards), executive fxn pseudodepressed |
| key components parietal | nondominant=visuospatial (ie drawing), dominant=praxis |
| key components lateral temporal | dominant=speech, nondominant=understanding prosody (emotl content of speech**1 language component handled by non dominant), also auditory perception and vocabulary |
| where's lesion if trbl pairing things | lateral temporal |
| what are 2 main parts of medial temporal | hippocampus and amygdala |
| key components hippocampus, 2 dz in which affected | short term memory storage/retrieval and consolidating short term into long term, affected in AD and temporal lobe epilepsy |
| key components amygdala | emotionally charged memories (overlap w primary olfactory, ie power of smells), aversive conditioning |
| how is dominance determined | where language center is |
| MC site of epilepsy in adult | hippocampus (ie medial temporal) |
| drawing all animals the same would be injury where | lateral temporal |
| where do sympathetic and parasympathetic tracts start | hypothalamus |
| where's the red nucleus, what is it | in midbrain, where Cb synapse |
| describe pt HM | had hippocampus and amygdala removed bilaterally and couldn't form any new memories (hippocampus consolidation short term memory to long term memory), but had procedural memory and would improve on tasks |
| sources of posterior circulation and anterior circulation and relation to structures | anterior circulation from carotid (includes m cerebral), near optic chiasm; posterior circulation from vertebral, near brainstem |
| which side do Cb lesions affect | SAME SIDE (ipsi) bc dbl crossed |
| s/s of lateral medulla stroke | ipsi horner, ipsi face incl dysphagia/gag, ipsi ataxia, contra body |
| what does MLF connect | CN3,6 for horiz gaze |
| key differentiating feature for INO | they can still converge |
| which CN exits from back of head | CN 4 |
| where does CNI synapse | in medial temporal lobe (not in brainstem) |
| where does CNII synpase | in thal (LGN) |
| L SCM turns head which way? | to the R |
| if lesion CN12 which way tongue | ipsi |
| if lesion CN9,10 which way uvula | away (contra) |
| compare spasticity and rigidity | spasticity is velocity dependent (resistance incrses the faster you go), rigidity is steady tension that's equal in opposing mscl grps |
| what are cortical sensory fxn tests? What does it test? | stereognosis (ID object by touch), graphesthesia (ID |
| what is responsible for bringing perceived threat to your attn | amygdala and thalamus |
| what is a 3+ on DTR? 4+? | 3+=spread to other motor neurons, 4+=clonus |
| on mscl power what is 3/5? 4/5? | 3=full motion w/o gravity, 4=motion w gravity |
| if can't adduct leg what nerve? Hamstring? Calf? | adduct=obturator, hamstring=sciatic, calf=tibial |
| 2 parts of Cb and what control | vermis=axial, flocculonodular=vestibular balance |
| how is sensory ataxia difft from Cb ataxia | Cb ataxia has wide based walk and look drunk, sensory ataxia worse in dark |
| what's festination | walking progressively faster bc falling fwd, ie propulsion |
| what's steppage gait | lift foot high 2/2 foot drop (peroneal n and anterior tibialis mscl) |
| waddle gait seen in which types of dzs | prox mscl wknss |