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Pharm facts

Pharm facts from Dr. Elliott

Beta-lactams penicillins, cephalosporins, carbepenams, monobactams
Penicillins not recommended as monotherapy for infectinos of eye, prostate, CNS (except meningitis)
Cephalosporins 1st gen activity Gram (+) with small Gram (-) activity
Cephalosporins 2nd gen activity inc. Gram (-) activity
Cephalosporins 3rd gen activity Gram (-) activity with small Gram (+)
Cephalosporins Cross-sensitivity ≤5% pts with penicillin allergy BUT better safe (literature says 10%)
Macrolides in respiratory generally good for respiratory infections
Azithromycin macrolide drug-drug interaction doesn't inhibit P-450
Erythromycin macrolide coverage & interactions Similar antibacterial coverage as PenG, Inhibits cytochrome P450 & causes MANY drug-drug interactions
Adverse effects among macrolides nausea, vomiting, diarrhea, upset stomach, gastric distress
Clindamycin MOA 50S ribosome inhibits bacterial protein synthesis
UTI Sulfonamides used primarily for UTI (FORCE oral fluids to prevent cystalluria)
DON'T use in G6PD sulfonamides (hemolyze & become anemic)
TMP/SMX trimethoprim sulfamethoxazole (tx & prophylaxis for P. jiroveci)
Respiratory infection prevelance major cause of morbidity from acute illness in US & top 3-5 reason for pt visits
To dx uncomplicated LRI Hx, PE, CXR, sputum smear/culture
Quinolones in LRI sometimes useful but inc. resistance
Dec. bioaviability in floroquinolones Divalent &/or trivalent cations dec. oral bioavailability of fluoroquinolones
Tetracyclines tx what? clamydophylial, brucellosis, mycoplasma pneumonia, rickettsial, or Lyme
Tetacyclines category in pregnancy Category D in pregnancy
Tetracyclines CI in chidlren <8yo
CAP S. pneumoniae
HAP S. areaus & gram (-)
Aspiration pneumoniae anaerobic bacteria
Created by: 903110321



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