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Nephrology-IM
IM
Question | Answer |
---|---|
What are the three main causes of Acute kidney injury? | Pre-renal, intrinsic renal, post-renal |
What are the causes of pre-renal kidney injury? | Hypovolemia, CHF, peripheral vasodilation, renal artery partial obstruction, cirrhosis, hepatorenal syndrome, ACE-I, NSAIDS |
What are the causes of intrinsic renal injury? | ATN, Glomerular disease, vascular (TTP, HUS), intersitial disease |
What are the causes of post-renal kidney injury? | increase tubular pressure with intact renal blood supply. Obstruction due to BPH, stones, CA. |
What are some of the signs of chronic kidney disease? | CV(HTN, CHF, uremic pericarditis), GI(N/V, anorexia), neuro(lethargy, confusion, seizures), Heme(normocytic, platelet dysf), endo(hypoCa, pruritis), electrolytes(hyperK/Mg). |
What is the treatment for chronic kidney disease? | ACE-I to decrease proteinuria, oral Ca, EPO, pruritis(capsaicin cream, cholestyramine, UV light). |
Under what circumstances would you do dialysis(acutely)? | "A-E-I-O-U" -->acidosis, electrolyte abnormality(HYPERKALEMIA), Ingestion of substances (like barbiturates, salicylates, lithium, methanol), Overload fluid (unresponsive to diuretics), Uremia symptoms (pericarditis, encephalopathy) |
When is hematuria considered abnormal? | When 3 RBC/hpf |
How can you tell if hematuria is glomerular or non-glomerular? | Glomerular=dysmorphic RBCs, RBC casts, and proteinuria. Non-glomerular=isomorphic RBCs, no protein or RBC casts |
Exam Q: given a pt. with hematuria that show up as dysmorphic RBCs, casts and also have proteinuria. They give you a C' value which is low. What are the possible causes? | "MISCC"=Membranoproliferative GN, Infection(post strep), SLE, Cryoglobulinemia, Cholesterol emboli syndrome. |
EXAM Q: Pt. is given an antibiotic medication and presents with the following triad--> rash, fever, eosinophils and blood in urine. Whats the diagnosis? | Allergic interstitial nephritis-->drug rxn to PCN, NSAIDS, diuretics, anticoagulants, phenytoin, sulfa |
By what age will pts with ADPKD experience end stage renal disease? | 50% of pts will have it by the late 50s-60s |
Pt presents with Hematuria, abd pain, HTN, and palpable kidneys. The pt tells you that his uncle had a brain aneurysm when he was 50 yrs old. DX? | ADPKD |
How do you diagnose ADPKD? | US |
What is Medullary sponge kidney? | Cystic dilation of collecting ducts; +/- hematuria, UTIs, stones |
How do you diagnose Medullary Sponge kidney? | IVP=intravenous pyelogram |
What is the mcc of secondary HTN? | Renal artery stenosis |
What are the 2 main causes of Renal artery stenosis? | Atherosclerosis(older) or Fibromuscular dysplasia(young women-->bilat in 50%). |
Exam Q: Pt. comes in with HTN, renal failure and abd bruit. Diagnosis? | Renal artery stenosis |
EXAM Q: pt comes in with HTN hematurian, flank pain and worsening renal function. Diagnosis? | Renal vein thrombosis |
How do you diagnos renal artery stenosis? | renal arteriogram vs. MRA or captopril renal scintogram |
How do you diagnos renal vein thrombosis? | renal venography or IVP |
EXAM Q: Pt. presents with flank pain radiating to the testical/labia. Diagnosis? | Nephrolithiasis |
Which kidney stones are radio-opaque? | Calcium (bipyramidal or biconcave) and struvite(rectangular prisms) |
Which kidney stones are radiolucent? | Uric acid (flat squares) and Cystine (hexagon-shaped crystals) |
Which kidney stones will show up on XRAY? | calcium and struvite |
Which kidney stones will show up on CT? | Most sensitive for all stones |
When do you need to consult urology in a pt who has kidney stones? | If a pt has CT and is found to have stone >1cm they are unlikely to pass spontaneously and you need to consult urology |
95% of prostate cancers are ________carcnioma? | Adenocarcinoma |
Should men have PSA screening? | Controversial. PSA testing should be discussed with the patient about the pros and cons of PSA testing. |
How do you diagnose Prostate cancer? | DRE +/- PSA |
What is the next step when you have a PSA>10 in a patient you have decided to screen? | Transrectal US biopsy. |
Hematuria, abd/flank pain, abd mass, fever, wt. loss, polycythemia, anemia. DIAGNOSIS? | Renal cell cancer |
What are the major risk factors for renal cell cancer? | Smoking, Phenacetin, ADPKD, ESRD |
How does Renal cell cancer metz? | hematogenously |
90% of bladder cancers are __________cell | Transitional cell |
Hematuria +/- dysuria/frequency. Diagnosis? | Bladder cancer |
When should you investigate hematuria? | ALWAYS |
Pt. is found to be hyponatremic-->next step? | Look at BP-->if its low then get a urine Na. |
Pt. is found to be hyponatremic-->you find that they are hypovolemic-->so you get a Una-->it's found to be high. What does that mean? | It means that the kidney is not working properly. If a pt. is hyponatremic and volume down the kidney should be saving Na+. Another problem could be that the patient is taking too many diuretics. |
Pt. is found to be hyponatremic-->you find that they are hypovolemic-->so you get a Una-->it's found to be low. What does that mean? | This means that the kidney is doing its job and saving Na+ since the body is low in Na+. It means the the Na+ is being lost by other means-->N/V/D. |
What will the Una be in a patient that has hyponatremia-hypovolemia which is due to extrarenal losses? | Una<10 |
What will the Una be in a patient that has hyponatremia-hypovolemia which is due to ATN, diuretics? | Una>20 |
What is the mcc of a pt with Hyponatremia-Euvolemia? | SIADH-->Una >40 |
What are the causes of Hyponatremia-Hypervolemia? | CHF, nephrotic syndrome, cirrhosis |
What is the cause of Hypernatremia (in general)? | Loss of water (extrarenal loss such as Skin, lungs, GI) or retention of Na+ (high Na intake, mineralocorticoid excess) |
What is the treatment for hypercalcemia? | NS(causes calciuresis), Bisphosphinates, Calcitonin, Steroids if Vit D excess, |
What are the 2 general causes of hypocalcemia? | Absence of PTH effect or Absence of Vit D effect |
What are the main causes of hypokalemia? | GI losses low Uk <20, renal losses high Uk >20, decreased intake, intracelluar shift (insuline, B2 agonists etc). |
What will the EKG look like in a patient with hypokalemia? | T waves flattened or inverted-->U waves |
What physical exam findings might you find in a pt with hypokalemia? | decreased DTR's, weakness |
Treatment of hypokalemia? | Oral KCL, if K< 2.5 or arrhythmia, IV KCL slowly |
What are the general causes of hyperkalemia? | High total body K(renal failure, addison's, spironoloactone), Redistribution (acidosis), pseudohyperkalemia |
What wil lthe EKG look like in hyperkalemia? | Diffuse peaked T waves-->long QT-->long PR-->P loss--> sign wave |
How do you treat a pt with severe hyperkalemia (>7) or pt who has EKG changes? | give calcium first b/c at cellular level that will counteract K+ effect on depolarization. Then after you save their heart acutely-->do dialysis for K+ |
Pt. comes in with weakness and their EKG shows flattened T wave. What is the next step in managment? | order serum K+ |
Pt with DKA has hyperkalemia. How do you correct this? | You need to give K+ when you correct their pH b/c if you don't the K+ will drop dramatically |
Causes of High Anion gap? | MUDPILES=Methanol, uremia, DKA, Paraldehyde, Iron/INH, Lactic acid, Ethanol/Ethylene glycol, Salicyclates |
High anion gap and optic neuritis/retinal edema. Whats the cause? | Methanol |
High anion gap and high Cr. What's the cause? | Uremia |
High anion gap and Ketones in urine and blood. What's the cause? | DKA |
High anion gap and TB prophylaxis treatment. What is the cause? | Iron/INH |
High anion gap and lactic acid increase. What is the cause? | Ischemia some where |
Homeless patient with high anion gap and oxalate crystals in urine. What is the cause? | Ethanol/Ethylene glycol |
High anion gap and initial acute resp alkalosis followed by acute metabolic acidosis. What is the cause? | Salicyclates |
Diagnosis: Pt with high HCO3, high pH, hypokalemia | Metabolic alkalosis |
What is the next step in management in a patient who you suspect has metabolic alkalosis? | check urine chloride to determine where cl- is being lost. Salt-sensitive (Ucl<10)-->due to V/D |