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Question | Answer |
---|---|
EPO levels in Polycythemia Vera? | low (high would imply theres hypoxia...which there isnt) |
what do you give for refractory pruritis in PV? | IFN-a |
What Ig's are increased in multiple myeloma? What cell types are incrased? | IgG, IgA (IgM is Waldenstrom's Macroglobulinemia). Cell type= plasma cell |
Bence Jones proteins are found in the urine of which dz? | Multiple Myeloma. B-J proteins = kappa/gamma light chains |
What do serum protein levels look like in MM | total proteins are raised, but albumin is normal (IgG/IgA cause the protein increase) |
HL age, and unique cell type? Most common type? | age = bimodal (young and elderly). unique cell= Reed Sternberg ((o)(o)). common type of HL= nodular sclerosing |
Starry sky appearance is what dz? what chromosomal abnormality is present? | Burkitt Lymphoma (a type of NHL)..due to EBV infxn. t8;14 |
Chemo therapy in HL can lead to ________ | secondary malignancy in breast/lung |
Leukemia common in Downs? | ALL |
what cell type precursors are present in ALL | B cell |
myoloperoxidase postive blasts are found in ________ | AML (duh, myeloid cells stain with MYELOperoxidase) |
a-naphthylesterase+ implies ? | M5 variant of AML |
smudge cells are found in ________ | CLL |
Chromosomal abn in CML? | 9;22 |
What type of leukemia has blast crisis? | CML |
drug used to treat CML? | imatinib (tyrosine kinase inh, since BCR-ABL is tyrosine kinase gene) |
TRAP+ stain is in _______ | hairy cell leukemia |
tumor lysis causes __K+, ____Ca, ____PO4, ______uric acid | all raised except Ca (it binds the PO4) |
Rx for anorexia caused by cancer? | Megestrol Acetate (progesterone derivative) |
difference in cell's involved btwn Fanconi Anemia and Diamond Blackfan (both have a shitload of congenital malformations) | FA= all blood cells involved (hypocellular bone marrow). DBF= only RBCs |