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tentwo
10-2
| Question | Answer |
|---|---|
| What blood test monitors the following: Heparin, Warfarin, LMWH? | heparin: PTT. LMWH: anti-FXa. Warfarin: PT (i.e. INR) |
| difference btwn mechanism of action of regular heparin and LMWH? | hep: increases AT III. LMWH: lowers FXa |
| What drugs are given in HIT | thrombin inhibitors (lepivudin, argatroban)...switch to warfarin once plt's are 100k |
| best diagnostic test for HIT? | serotonin release assay |
| HIT is similar to what other thrombocytopenia as far as mechanism of action goes? | ITP (both are anti-platelet antibody mediated) HIT-->anti PF-4 |
| TTP (after HUS) mechanism? | anti- vWF antibodies (as opposed to ITP/HIT which is anti platelet ABs) |
| how do you determine if HUS has progressed to TTP? | neuro symptoms + fever |
| if HELLP develops in pregnant female, what is next step? | if <34w, give steroids and anti-HTNives. If >34w, deliver that shit |
| Common manifestation of Von WIllebrand's dz in women? | menorrhagia (give OCP) |
| Which bleeding parameters go up in vW Dz? Rx for vW Dz? | PTT, BT. Treat with DDAVP (releases vWF) acutely, give cryoprecipitate/FVIII long term |
| association of vitK and gut flora? | gut flora PRODUCE vitK so ABx cause low vitK levels (as opposed to vit B12 which gets f****d by flora cuz they cause malabsorption) |
| difference in bleeding parameters btwn vW dz and hemophilia? | vWF: raised PTT AND BT (plt's). Hemophilia is ONLY PTT |
| bleeding parameters in DIC? | all are raised (PTT, PT, BT) |
| if Candida causes sepsis, what antifungal do you give? | Ampho B (this is usually the choice for any crazy ass fungal infxn, including severe histoplasmosis) |
| What is SIRS (systemic inflammatory response syndrome)?? | precursor to sepsis: it has hyperventilation, tachycardia, raised or lowered WBCs, Fever or Hypothermia |
| sub saharan africa/india Malaria drug? | mefloquine (these areas are chloroquine resistant) |
| Atypical T Cells (downy cells) are seen in which infection? | Infectious Mononucleosis (EBV) |
| Rx of mononucleosis (EBV) | just NSAIDS (no antivirals!) |
| how do you treat Kaposi sarcoma | aliretinoin |
| Rx of PCP | tmp smx |
| Yellow infiltrates of retina in CD <50? | CMV retinitis |
| 3 places CMV affects HIV pt's | retina, esophagus, GIT (diarrhea) |
| Treatment of MAC in CD<50? | clarithromycin/azithromycin (one is prophylaxis and one is treatment, cant remember which) |
| Best HIV screening test? | ELISA x2 |
| Best HIV confirmation test? | Western Blot |
| pregnant HIV pt...what guidelines must be followed? | Do C section, give ZDV to mother and child, NO BREAST FEEDING |
| best screening for HIV in neonate? | viral load (ELISA will always be + because of mom's ABs) |
| 3 parameters for starting anti-retrovirals | CD <350, viral load >20,000, opportunistic infxn |
| HIV drug side affects | Indinavir (protease inhibitor) = crystal-induced nephropathy Abacavir = lactic acidosis, hepatitis AND hypersensitivity syndrome Nucleoside RTIs (Zidovudine, Lamivudine) = lactic acidosis NNRTIS (Nevirapine) = liver failure |
Created by:
jsad
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