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10-1
Question | Answer |
---|---|
cold agglutinin infections? | Mycoplasma, EBV |
burr cells (spikey membranes) are found in which anemia? | hemolytic anemia |
bite cells occur in ________. Cause? | G6PD def. They occur because Heinz bodies are present and the spleen bites the shit out of those |
Iron absorption is affected in what way if GI acid is low? | it goes down |
what type of murmur does IDA cause | systolic |
RDW is >20% in which microcytic anemia? | IDA (multiple cell sizes). Used to distinguish from thalassemia |
Ferritin levels in Anemia of Chronic Disease? | Raised (Iron is a inflammatory marker). Therefore TIBC is low |
target cells are found in? | alpha thalasemia |
Diphylobothrium infxn causing B12 deficiency. Treatment? | Praziquantel |
Which runs out quicker: folate or B12? | Folate |
What happens to Iron in ACD? | It is trapped in macrophages |
EPO levels in ACD? | low (give EPO supplementation) |
Treatment of hereditary sideroblastic anemia? Treatment of acquired sideroblastic anemia? | hereditary: B6. acquired: EPO |
What a-thalassemia requires transfusions | (--,-a) [because HbH forms {BB,BB}] the rest either kill you in utero (--,--) or cause mild anemias |
HbF chains? HbA2? | (a2,g2); (a2,d2) HbF is fetal. HbA2 increases in B-thalassemia major |
What B-thalassemia requires transfusion? | B-thal Major (-,-) |
Fish mouthing of vertebrae occurs in? | sickle cell crisis (bone pain) |
What is Howell-Jolly body? | nuclear remnant in RBCs. Due to asplenia in SCD patients |
Best Rx for sickle cell CRISIS? | o2, hydration, analgesics...HbF |
What causes aplastic crisis in SCD pt? | Parvovirus B19 |
Febrile neutropenia requires what measure? | immediate hospitalization |